Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (10): 2031-2045.DOI: 10.6023/cjoc201307010 Previous Articles     Next Articles

ACCOUNT

双模式Lewis Acid介导串联环化反应在天然产物全合成中的应用

朱礼志, 杜广延, 杨炜, 闵龙, 刘小卒, 黄双平, 韩叶俭, 李志成   

  1. 北京大学深圳研究生院 化学生物学与生物技术学院 化学基因组学实验室 深圳 518055
  • 收稿日期:2013-07-06 修回日期:2013-08-09 出版日期:2013-10-25 发布日期:2013-08-16
  • 通讯作者: 李志成 E-mail:lizc@pkusz.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 20672003, 20972004, 21272012 )资助项目

Applications of Dual-Mode Lewis Acids Induced Cascade Cyclization Reactions in Natural Product Synthesis

Zhu Lizhi, Du Guangyan, Yang Wei, Min Long, Liu Xiaozu, Huang Shuangping, Han Yejian, Lee Chi-Sing   

  1. Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055
  • Received:2013-07-06 Revised:2013-08-09 Online:2013-10-25 Published:2013-08-16
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20672003, 20972004, 21272012).

This account covers the recent advance of the dual-mode Lewis acid induced cascade cyclization reactions in our group. Taking advantage of the special properties of the dual-mode Lewis acids, three new types of cascade reactions have been developed. Moreover, the applicability of the cascade cyclization reactions was explored through studying the scope of substrates. Finally, these reactions were employed for total syntheses of natural products.

Key words: dual-mode Lewis acid, cascade cyclization reaction, total syntheses of natural product