Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (8): 1673-1676.DOI: 10.6023/cjoc201403016 Previous Articles     Next Articles



陈翠, 谭丽泉, 邱会华   

  1. 广东石油化工学院化学工程学院 茂名 525000
  • 收稿日期:2014-03-07 修回日期:2014-04-02 发布日期:2014-04-18
  • 通讯作者: 陈翠
  • 基金资助:

Synthesis of Multi-substituted 1,4-Dihydropyridine Derivatives from Acetoacetanilides

Chen Cui, Tan Liquan, Qiu Huihua   

  1. College of Chemcal Engineering, Guangdong University of Petrochemical Technology, Maoming 525000
  • Received:2014-03-07 Revised:2014-04-02 Published:2014-04-18
  • Supported by:
    Project supported by the Natural Science Foundation of Guangdong Province (No. S2012040007868).

This paper reports a simple intermolecular condensation reaction for the synthesis of 1,4-dihydropyridine derivatives from acetoacetanilides using AcOH as the solvent and ammonium persulfate[(NH4)2S2O4] as the oxidant. The structures of products were confirmed by IR, 1H NMR, 13C NMR and HR-MS. In addition, a possible reaction mechanism was proposed.

Key words: ammonium persulfate, intermolecular condensation, 1,4-dihydropyridine derivatives, acetoacetanilides