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Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (8): 1677-1681.DOI: 10.6023/cjoc201403017 Previous Articles     Next Articles

Notes

裸蒴中四个新的联苯四氢呋喃型木脂素

肖世基a,b, 方冬梅a, 夏兵a, 徐林峰c, 徐宏喜c, 蒋艳a, 陈放b, 丁立生a, 周燕a   

  1. a 中国科学院成都生物研究所 成都 610041;
    b 四川大学生命科学学院 成都 610041;
    c 上海中医药大学中药学院 上海 201203
  • 收稿日期:2014-03-07 修回日期:2014-04-07 发布日期:2014-04-18
  • 通讯作者: 丁立生，周燕 E-mail:lsding@cib.ac.cn;zhouyan@cib.ac.cn
  • 基金资助:

    国家自然科学基金（Nos.30973635，21302180）资助项目.

Biphenyl Lignans with a Tetrahydrofuran Moiety from Gymnotheca chinensis Decne

Xiao Shijia,b, Fang Dongmeia, Xia Binga, Xu Linfengc, Xu Hongxic, Jiang Yana, Chen Fangb, Ding Lishenga, Zhou Yana   

  1. a Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041;
    b College of Life Science, Sichuan University, Chengdu 610064;
    c Shanghai University of Traditional Chinese Medicine, Shanghai 201203
  • Received:2014-03-07 Revised:2014-04-07 Published:2014-04-18
  • Supported by:

    Project supported by the National Natural Sciences Foundation of China (Nos. 30973634, 21302180).

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Supporting Info.

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Cited

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Four new biphenyl lignans with a tetrahydrofuran moiety, named gymnothelignans X1, X2, Y1, and Y2 (1～4), were isolated from the methanol extract of the whole plants of Gymnotheca chinensis Decne. The chemical structures were established by means of spectroscopic analysis including 1D and 2D NMR spectroscopy and HR-ESIMS. Compound 1 exhibited moderate cytotoxicity against the HCT116, HCT15, A549, MCF-7 and HepG2 cancer cell lines with IC50 values of 18.4, 11.2, 26.5, 9.1 and 23.5 μmol·L-1, respectively.

Key words: saururaceae, Gymnotheca chinensis, atropisomer, biphenyl lignan, gymnothelignan