Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (4): 910-916.DOI: 10.6023/cjoc201410034 Previous Articles     Next Articles



李培源, 张建瑞, 郭胜海, 张新迎, 范学森   

  1. 河南师范大学化学化工学院 河南省精细化学品绿色制造协同创新中心 新乡 453007
  • 收稿日期:2014-10-24 修回日期:2014-11-22 发布日期:2014-12-09
  • 通讯作者: 范学森, 张新迎;
  • 基金资助:

    国家自然科学基金(Nos. 21172057, 21272058, 21202040)及教育部博士点基金(No. 20114104110005)资助项目.

New Synthesis of Brivudine and Its Analogs

Li Peiyuan, Zhang Jianrui, Guo Shenghai, Zhang Xinying, Fan Xuesen   

  1. School of Chemistry and Chemical Engineering, Collaborative Innovation Centre of Henan Province for Green Manufacturing of Fine Chemicals, Henan Normal University, Xinxiang 453007
  • Received:2014-10-24 Revised:2014-11-22 Published:2014-12-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172057, 21272058, 21202040), and the Research Fund for the Doctoral Program of Higher Education (No. 20114104110005).

In this paper, a simple and practical method for the preparation of brivudine (BVDU) and its analog nucleoside derivatives via condensation of the easily obtainable 5-formyl pyrimidine nucleosides with carbon tetrabromide followed by an efficient and stereoselective debromination promoted by diethyl phosphite and triethylamine is presented.

Key words: brivudine, gem-dibromoalkenes, debromination