Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (4): 898-904.DOI: 10.6023/cjoc201411026 Previous Articles     Next Articles



李建晓a, 李春生a, 杨少容a, 罗维b   

  1. a 华南理工大学化学与化工学院 广州 510640;
    b 华南理工大学分析测试中心 广州 510640
  • 收稿日期:2014-11-14 修回日期:2014-12-03 发布日期:2014-12-15
  • 通讯作者: 杨少容
  • 基金资助:

    国家自然科学基金(Nos. 21102047, 31101221)资助项目.

Chloropalladation Triggering the Cascade Annulation to Construct Functionalized Saturated γ-Lactones in Ionic Liquids

Li Jianxiaoa, Li Chunshenga, Yang Shaoronga, Luo Weib   

  1. a School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640;
    b Analytical and Testing Center, South China University of Technology, Guangzhou 510640
  • Received:2014-11-14 Revised:2014-12-03 Published:2014-12-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21102047, 31101221).

A highly efficient and mild palladium-catalyzed cascade annulation has been developed to afford functionalized γ-lactones in moderate to good yields with high regio- and diastereo-selectivities in ionic liquids. Their structures were confirmed by 1H NMR, 13C NMR and HRMS. Moreover, this reaction provided a novel and convenient methodology for the construction of naturally occurring biologically active γ-lactones.

Key words: ionic liquids, chloropalladation, alkynes, pent-4-enoic acid, saturated γ-lactones