Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 655-661.DOI: 10.6023/cjoc201412009 Previous Articles     Next Articles



李龙, 周波, 叶龙武   

  1. 固体表面物理化学国家重点实验室 福建省化学生物学重点实验室 厦门大学化学化工学院 厦门 361005
  • 收稿日期:2014-12-03 修回日期:2014-01-01 发布日期:2014-01-09
  • 通讯作者: 叶龙武
  • 基金资助:

    国家自然科学基金(Nos. 21102119, 21272191)和教育部创新团队资助项目.

Efficient and Practical Synthesis of α-Amino Amides through Gold-Catalyzed Intermolecular Oxidation of Ynamides

Li Long, Zhou Bo, Ye Longwu   

  1. State Key Laboratory for Physical Chemistry of Solid Surfaces & The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005
  • Received:2014-12-03 Revised:2014-01-01 Published:2014-01-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21102119, 21272191) and the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT).

α-Amino amides constitute an important category of carbonyl compounds which exist in a large number of bioactive natural and non natural molecules. In this paper, an efficient intermolecular reaction of gold carbene intermediates, generated through gold-catalyzed intermolecular oxidation of alkynes, with primary anilines has been realized in aqueous media. Importantly, this non-diazo approach provides a general and practical solution for the synthesis of various functionalized α-amino amides.

Key words: gold catalysis, α-amino amides, gold carbenoids, oxidation