Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (5): 1286-1306.DOI: 10.6023/cjoc202110028 Previous Articles     Next Articles



谢吴成*(), 陈浒, 黎韵越, 林洁玲, 陈婉雯, 石君君*()   

  1. 佛山科学技术学院 环境与化学工程学院 广东佛山 524200
  • 收稿日期:2021-10-19 修回日期:2021-12-29 发布日期:2022-01-11
  • 通讯作者: 谢吴成, 石君君
  • 基金资助:
    国家自然科学基金(22001036); 国家自然科学基金(21808032)

Electrooxidative Annulation of Unsaturated Molecules via Directed C—H Activation

Wucheng Xie(), Xu Chen, Yunyue Li, Jieling Lin, Wanwen Chen, Junjun Shi()   

  1. School of Environment and Chemical Engineering, Foshan University, Foshan, Guangdong 528000
  • Received:2021-10-19 Revised:2021-12-29 Published:2022-01-11
  • Contact: Wucheng Xie, Junjun Shi
  • Supported by:
    National Natural Science Foundation of China(22001036); National Natural Science Foundation of China(21808032)

Transition-metal catalyzed directed C—H bond activation and cyclization of unsaturated molecules have been developed as an efficient method to synthesize complex carbon aromatic and heteroaromatic compounds. However, additional stoichiometric oxidants are often required to realize the reoxidation cycle. Electrochemical organic synthesis can use current to replace expensive and toxic oxidants. It is an environment-friendly synthesis method. In recent years, remarkable progress has been made in the combination of electrochemical organic synthesis and C—H activation catalyzed by transition metals (such as Pd, Ni, Co, Ru, Cu, Rh, Ir, etc.). The latest progress of transition-metal catalyzed electrooxidative annulation of unsaturated molecules such as alkynes, olefins, carbon monoxide and isocyanogens via directed C—H activation is reviewed. Finally, the challenges and the future development on this important area are also described.

Key words: C—H bond activation, electrooxidation, cyclization, unsaturated molecule