Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (4): 827-834.DOI: 10.6023/cjoc201412045 Previous Articles     Next Articles



曾苏伟a, 徐森a, 王勇a, 喻敏a, 朱荔b, 姚小泉a   

  1. a 南京航空航天大学材料科学与技术学院 南京 210016;
    b 南京医科大学药学院 南京 210029
  • 收稿日期:2014-12-27 修回日期:2015-03-12 发布日期:2015-03-17
  • 通讯作者: 姚小泉
  • 基金资助:

    国家自然科学基金(No. 21172107)资助项目.

Copper Nanoparticles Catalyzed Three-Component Coupling of Alkyne, Dihalomethane and Amine for the Synthesis of Propargylic Amine

Zeng Suweia, Xu Sena, Wang Yonga, Yu Mina, Zhu Lib, Yao Xiaoquana   

  1. a Department of Applied Chemistry, Nanjing University of Aeronautics and Astronautics, Nanjing 210016;
    b School of Pharmacy, Nanjing Medical University, Nanjing 210029
  • Received:2014-12-27 Revised:2015-03-12 Published:2015-03-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21172107).

A copper nanoparticles-catalyzed three-component coupling reaction of alkyne, dihalomethane, and amine (AHA coupling) was reported for the synthesis of propargylic amine. The catalytic AHA coupling reaction was carried out under mild conditions with dihalomethane as substrate and solvent, and good to excellent yields were also achieved. Furthermore, the nanoparticle catalyst could be recovered and reused effectively, and no obvious reduction on catalytic activity was observed for five recycles.

Key words: copper nanoparticles, AHA coupling reaction, propargylic amines, catalyst recycling