Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (5): 1316-1322.DOI: 10.6023/cjoc201912003 Previous Articles     Next Articles


史大鹏a, 段中余a,b   

  1. a 河北工业大学化工学院 天津 300130;
    b 河北工业大学天津市本质安全化工技术重点实验室 天津 300130
  • 收稿日期:2019-12-03 修回日期:2020-01-09 发布日期:2020-01-21
  • 通讯作者: 段中余
  • 基金资助:

Propargylamine Synthesis via Three-Component Coupling Reaction Catalyzed by Recyclable Cu Nanoparticles under Solvent-Free Conditions

Shi Dapenga, Duan Zhongyua,b   

  1. a School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130;
    b Tianjin Key Laboratory of Chemical Process Safety, Hebei University of Technology, Tianjin 300130
  • Received:2019-12-03 Revised:2020-01-09 Published:2020-01-21
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 51473045).

In this paper, copper nanoparticles (Cu NPs) were synthesized from copper sulfate by hydrothermal method using hydrazine hydrate as reducing agent. The obtained catalyst was characterized by transmission electron microscope (TEM) and X-ray diffraction (XRD), and successfully used as heterogeneous catalyst to promote the three-component coupling reaction of phenylacetylene, amine and aldehyde in solvent-free. Under Cu NPs (10 mol%), 110℃ and reaction time 10 h,the catalyst exhibits excellent catalytic activity with 88% yield. It is worth noting that the catalyst system can maintain high catalytic activity with only a slight decrease after 4 cycles (all isolated yields >84%). A propargylamine synthetic method by three-component coupling reaction was provided possessing the advantages of simple post-treatment procedure, solvent-free, extensive substrate range and good reusability of catalyst.

Key words: copper nanoparticles, propargylamine, three-component coupling, solvent-free, recyclability