Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2589-2594.DOI: 10.6023/cjoc201505040 Previous Articles     Next Articles



谢明胜, 唐浩鑫, 张一铭, 郭真, 郭海明, 渠桂荣   

  1. 河南师范大学化学化工学院 新乡 453007
  • 收稿日期:2015-05-27 修回日期:2015-08-09 发布日期:2015-08-25
  • 通讯作者: 渠桂荣
  • 基金资助:

    国家自然科学基金(Nos. 21172059, 21372066, 21402041)、高等学校博士学科点专项科研基金(No. 20124104110006)和国家大学生创新性实验计划(Nos. 201310476035, 201410476027)资助项目.

A New Method for the Synthesis of Alkyl-Substituted 1,2,3-Triazole Compounds

Xie Mingsheng, Tang Haoxin, Zhang Yiming, Guo Zhen, Guo Haiming, Qu Guirong   

  1. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007
  • Received:2015-05-27 Revised:2015-08-09 Published:2015-08-25
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172059, 21372066, 21402041), the Research Fund for the Doctoral Program of Higher Education (No. 20124104110006), and the Creative Experimental Project of National Undergraduate Students (Nos. 201310476035, 201410476027).

1,2,3-Trizaole derivatives have been widely used in the fields of medicine pesticide and materials. Thus, much attention has been paid to the synthesis of various 1,2,3-trizaole derivatives. However, the transformation of function group at N(1) position of 1,2,3-triazole derivatives was less studied. In this paper, in the presence of base and using copper salt as the catalyst, the sulfonyl group of 1,2,3-triazole derivatives could be transformed to other function groups in a "one-pot two-steps" manner, including benzyl, substituted benzyl, halide substituted alkyl or alkyl groups. This method exhibited mild reaction conditions and simple operation. Meanwhile, based on the captured reaction intermediate, the reaction mechanism was also proposed.

Key words: 1,2,3-triazole, function group transformation, alkyl-substituted, one-pot two-steps