ortho-Dialkyl-Substituted Aromatic Acids from Verrucosispora sp. NS0172

doi:10.6023/cjoc201908033

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (4): 1038-1042.DOI: 10.6023/cjoc201908033 Previous Articles Next Articles

疣孢菌NS0172产生的邻二烷基取代芳香酸

张坤^a, 谢向前^b, 史海霞^a, 沈月毛^a,b, 王浩鑫^a

a 山东大学微生物技术研究院微生物技术国家重点实验室青岛 266237;
b 山东大学药学院天然产物化学生物学教育部重点实验室济南 250012

收稿日期:2019-08-26 修回日期:2019-11-08 发布日期:2020-05-06
通讯作者: 沈月毛, 王浩鑫 E-mail:yshen@sdu.edu.cn;wanghaoxin@sdu.edu.cn
基金资助:
国家自然科学基金（Nos.31570039，81530091）和教育部长江学者与创新团队发展计划（No.IRT_17R68）资助项目.

ortho-Dialkyl-Substituted Aromatic Acids from Verrucosispora sp. NS0172

Zhang Kun^a, Xie Xiangqian^b, Shi Haixia^a, Shen Yuemao^a,b, Wang Haoxin^a

a State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao 266237;
b Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012

Received:2019-08-26 Revised:2019-11-08 Published:2020-05-06
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 31570039, 81530091), and the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT_17R68).

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Abstract

Two new ortho-dialkyl-substituted aromatic acids 1 and 2 were isolated from Verrucosispora sp. NS0172. The chemical structures of 1 and 2 were determined by spectroscopic methods including 1D- and 2D-NMR and HR-ESIMS experiments. The cytotoxicity of compounds 1 and 2 was evaluated by methyl thiazolyl tetrazolium (MTT) assay, and compound 1 showed potent antiproliferative activity against human hepatocellular carcinoma SMMC-7721 (IC₅₀ 7.74 μmol·L^-1). Compounds 1 and 2 were tested for the antimicrobial and antifungal activities by filter paper disc diffusion assay, and both of them showed no evident activities at a dose of 40 μg/disc. This study is the first report of discovering of ortho-dialkyl-substi-tuted aromatic acids from Verrucosispora, which sets the foundation for future biosynthetic study of this class of natural products in Verrucosispora.

Key words: verrucosispora, actinomycetes, natural product, ortho-dialkyl-substituted aromatic acids

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Zhang Kun, Xie Xiangqian, Shi Haixia, Shen Yuemao, Wang Haoxin. ortho-Dialkyl-Substituted Aromatic Acids from Verrucosispora sp. NS0172[J]. Chinese Journal of Organic Chemistry, 2020, 40(4): 1038-1042.

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疣孢菌NS0172产生的邻二烷基取代芳香酸

ortho-Dialkyl-Substituted Aromatic Acids from Verrucosispora sp. NS0172

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