Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (3): 659-663.DOI: 10.6023/cjoc201509037 Previous Articles     Next Articles



林志兰, 张俊民, 高原   

  1. 深圳大学化学与环境工程学院 深圳 518060
  • 收稿日期:2015-09-28 修回日期:2015-10-26 发布日期:2015-11-06
  • 通讯作者: 高原
  • 基金资助:

    国家自然科学基金(No. 21402124)资助项目.

A Convenient Method to Prepare Pyrano[2,3-d]pyrimidine Derivatives

Lin Zhilan, Zhang Junmin, Gao Yuan   

  1. College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060
  • Received:2015-09-28 Revised:2015-10-26 Published:2015-11-06
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21402124).

A series of pyrano[2,3-d]pyrimidine derivatives were synthesized by the reaction of 2-amino-3-cyano-4H-pyrans with acetic anhydride. This method has the advantages of short reaction times (10~15 min), simple operation and convenient post-treatment. All products were fully characterized by IR and 1H NMR spectra. The molecular structures of 4a and 6a were confirmed using single-crystal X-ray analyses.

Key words: pyrano[2,3-d]pyrimidine derivatives, 2-amino-3-cyano-4H-pyran derivatives, acid catalysis