Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (5): 1122-1126.DOI: 10.6023/cjoc201512013 Previous Articles     Next Articles

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氯甲基甲醚的高效合成及其一锅法保护羟基

郑东青a, 曹伟a, 马海燕a, 丁凯b   

  1. a. 华东理工大学金属有机实验室 上海 200237;
    b. 中国科学院上海有机化学研究所 天然产物合成重点实验室 上海 200032
  • 收稿日期:2015-12-09 修回日期:2016-01-05 发布日期:2016-01-15
  • 通讯作者: 马海燕, 丁凯 E-mail:haiyanma@ecust.edu.cn;dingkai@mail.sioc.ac.cn
  • 基金资助:

    国家自然科学青年科学基金(No.20902098)资助项目.

Efficient Synthesis of Chloromethyl Methyl Ether and One-Pot Hydroxyl Protection

Zheng Dongqinga, Cao Weia, Ma Haiyana, Ding Kaib   

  1. a. Laboratory of Organometallic, East China University of Science and Technology, Shanghai 200237;
    b. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2015-12-09 Revised:2016-01-05 Published:2016-01-15
  • Supported by:

    Project supported by the National Natural Science Foundation for Young Scientists of China (No. 20902098).

Chloromethyl methyl ether (MOMCl) is an important protecting agent in organic synthesis. An efficient synthesis of chloromethyl methyl ether is reported and a one-pot hydroxyl protection procedure is developed. The method features mild condition, short reaction time, high yield and simple operation.

Key words: chloromethyl methyl ether, hydroxyl protecting agent, one-pot