Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (7): 1706-1711.DOI: 10.6023/cjoc201512025 Previous Articles     Next Articles



高亚年, 张梦烨, 钱海燕, 谢倩雯, 陈明, 徐双双, 荣良策   

  1. 江苏师范大学化学化工学院 徐州 221116
  • 收稿日期:2015-12-20 修回日期:2016-02-25 发布日期:2016-03-11
  • 通讯作者: 荣良策,
  • 基金资助:


A Rapid and Green Synthesis of 8-Aryl-5,7,7-tricyanoisoquinoline Derivatives at Room Temperature under Solvent-Free and Catalyst-Free Conditions

Gao Yanian, Zhang Mengye, Qian Haiyan, Xie Qianwen, Chen Ming, Xu Shuangshuang, Rong Liangce   

  1. School of Chemistry and Chemical Engineering, Jiangsu Normal University, Xuzhou 221116
  • Received:2015-12-20 Revised:2016-02-25 Published:2016-03-11
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21571087), and the Brand Major of Universities in Jiangsu Province.

A facile and rapid synthesis of 8-aryl-5,7,7-tricyanoisoquinoline derivatives from the reaction of aromatic aldehydes, malononitrile, and N-substituted-4-piperidones at room temperature under solvent-free and catalyst-free conditions. The N-ethylpiperidin-4-one was first used for the synthesis of 6-amino-2-ethyl-8-aryl-2,3,8,8a-tetrahydroisoquinoline-5,7,7(1H)- tricarbonitrile derivatives. This method offers several advantages in terms of its mild conditions, available raw materials, simple operation, high yields, short reaction time and green process. The products were identified by IR, 1H NMR and HRMS. The reported method is the efficient approach for the synthesis of isoquinoline derivatives.

Key words: isoquinoline, N-ethylpiperidin-4-one, ethyl 4-oxopiperidine-N-carboxylate, green synthesis