Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (6): 1308-1315.DOI: 10.6023/cjoc201602024 Previous Articles     Next Articles



宋然a, 袁斌骅a, 孙兴文a, 林国强b   

  1. a 复旦大学化学系上海 200433;
    b 中国科学院天然产物有机合成化学重点实验室上海 200032
  • 收稿日期:2016-02-24 修回日期:2016-04-05 发布日期:2016-04-15
  • 通讯作者: 孙兴文
  • 基金资助:


A Convenient Access to 1-Aminoindans via Intramolecular Heck Reaction

Song Rana, Yuan Binhuaa, Sun Xingwena, Lin Guoqiangb   

  1. a Department of Chemistry, Fudan University, Shanghai 200433;
    b CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai 200032
  • Received:2016-02-24 Revised:2016-04-05 Published:2016-04-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21472019).

The aminoindan skeleton, which widely exists in natural products and drug molecules. A convenient approach, aza-Barbier reaction and intramolecular Heck reaction, was successfully developed for the construction of this skeleton. Enantioenriched 3-methylene-1-amino-2-indanol was also synthesized via this method.

Key words: aminoindan, aza-Barbier reaction, intramolecular Heck reaction