Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (9): 2136-2141.DOI: 10.6023/cjoc201603043 Previous Articles     Next Articles



安艳妮, 李建晓, 张振明, 李春生, 杨少容   

  1. 华南理工大学化学与化工学院 广州 510640
  • 收稿日期:2016-03-27 修回日期:2016-04-14 发布日期:2016-05-17
  • 通讯作者: 李建晓, 杨少容
  • 基金资助:


Bromopalladation Triggering the Cascade Oxidative Heterocyclization Reaction of Alkynes with Alkenes in Ionic Liquids

An Yanni, Li Jianxiao, Zhang Zhenming, Li Chunsheng, Yang Shaorong   

  1. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640
  • Received:2016-03-27 Revised:2016-04-14 Published:2016-05-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21502055), the Fundamental Research Funds for the Central Universities (No.2015ZM150) and China Postdoctoral Science Foundation (No.2015M572303).

An efficient and practical palladium-catalyzed cascade oxidative heterocyclization has been developed to afford functionalized oxygen-containing five-membered heterocycles in moderate to good yields with high regio- and diastereo-selectivities. Their structures were confirmed by IR, 1H NMR, 13C NMR and HRMS. Furthermore, the current methodology could also be conveniently applied to the synthesis of naturally occurring biologically active functionalized tetrahydrofurans and γ-lactones frameworks.

Key words: palladium-catalyzed, ionic liquids, alkynes, alkenes, heterocycles