Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (9): 2039-2052.DOI: 10.6023/cjoc201603046 Previous Articles     Next Articles



张薇a,b, 徐妮为c, 姚子健b, 李宽b, 朱玉b, 陈良艳b, 叶文玲b, 邓维a,b   

  1. a 上海大学材料科学与工程学院 上海 200444;
    b 上海应用技术学院化学与环境工程学院 上海 201418;
    c 湖南中医药高等专科学校 株洲 412012
  • 收稿日期:2016-03-28 修回日期:2016-05-05 发布日期:2016-05-19
  • 通讯作者: 姚子健, 邓维;
  • 基金资助:


Recent Progress of Nucleic Acid Vector Based on Dendritic Polymers

Zhang Weia,b, Xu Niweic, Yao Zijianb, Li Kuanb, Zhu Yub, Chen Liangyanb, Ye Wenlingb, Deng Weia,b   

  1. a School of Materials Science and Engineering, Shanghai University, Shanghai 200444;
    b School of Chemical and Engineering, Shanghai Institute of Technology, Shanghai 201418;
    c Traditional Chinese Medical College, Zhuzhou 412012
  • Received:2016-03-28 Revised:2016-05-05 Published:2016-05-19
  • Supported by:

    Project supported by the Shuguang Scholar Project, the National Natural Science Foundation of China (Nos.21174081, 21601125) and the Natural Science Foundation of Shanghai City (No.16ZR1435700).

Secure and efficient gene carrier has important application in gene therapy. Compared with viral gene vectors, non-viral gene vec-tor has attracted much attention because of their low immunogenicity, easy mass production and low costs. However, they showed limited activity in transfection efficiency and selectivity. This paper reviewed recent research progress in dendritic poly-mers gene carriers, including (ⅰ) dendritic and derived materials, (ⅱ) supramolecular parent materials, such as the carrier combined with cyclodextrins, and cucurbituril in multivariate and block type pattern, (ⅲ) dendritic polymers gene vector combined with inorganic material, such as gold nanoparticles, iron oxide nanoparticles and graphene, and (ⅳ) functional response type dendritic polymers gene vector, such as the pH response type vector, two disulfide response type vector, redox hyperbranched gene carrier and fluorinated dendrimers as gene vectors.

Key words: hyperbranched polymer, gene delivery, dendrimer, gene therapy