Poly (amido amine)s with Different Branched Architecture: Synthesis, Reactivity and Their Application in Gene Delivery

doi:10.6023/cjoc201803006

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (10): 2713-2719.DOI: 10.6023/cjoc201803006 Previous Articles Next Articles

Articles

不同支化结构的聚酰胺胺的合成、活性及其在基因载体中的应用

张薇^a, 姚子健^a, 邓维^a,b

a 上海大学材料科学与工程学院上海 200444;
b 上海应用技术大学化学与环境工程学院上海 201418

收稿日期:2018-03-05 修回日期:2018-05-30 发布日期:2018-06-15
通讯作者: 邓维,E-mail:wdeng@shu.edu.cn E-mail:wdeng@shu.edu.cn
基金资助:
上海市教育委员会重点学科建设（No.J50704）和上海市自然科学基金（No.16ZR1435700）资助项目.

Poly (amido amine)s with Different Branched Architecture: Synthesis, Reactivity and Their Application in Gene Delivery

Zhang Wei^a, Yao Zijian^a, Deng Wei^a,b

a School of Materials Science and Engineering, Shanghai University, Shanghai 200444;
b School of Chemical and Engineering, Shanghai Institute of Technology, Shanghai 201418

Received:2018-03-05 Revised:2018-05-30 Published:2018-06-15
Contact: 10.6023/cjoc201803006 E-mail:wdeng@shu.edu.cn
Supported by:
Project supported by the Key Subject of Shanghai Municipal Education Commission (No. J50704) and the Natural Science Foundation of Shanghai City (No. 16ZR1435700).

1. Poly (amido amine)s with Different Branched Architecture: Synthesis, Reactivity and Their Application in Gene Delivery.PDF(1239KB)

Abstract

Poly (amido amine)s with diverse topographical structures are promising candidates for gene delivery and drug carriers. A series of poly (amido amine)s (PAAs) with the same repeating units, however, different degree of branching, were successfully prepared by Michael addition polycondensation of N,N-methylenebis (acrylamide) (MBA) and L-cysteine methyl ester hydrochloride (CYS) in a water/dimethyl sulfoxide co-solvent. The obtained disposed cationic PAAs exhibit good DNA condensation capacities.

Key words: poly(amido amine)s, branched polymer, gene delivery, L-cysteine methyl ester hydrochloride, cyclodextrin

Cite this article

Zhang Wei, Yao Zijian, Deng Wei. Poly (amido amine)s with Different Branched Architecture: Synthesis, Reactivity and Their Application in Gene Delivery[J]. Chin. J. Org. Chem., 2018, 38(10): 2713-2719.

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不同支化结构的聚酰胺胺的合成、活性及其在基因载体中的应用

Poly (amido amine)s with Different Branched Architecture: Synthesis, Reactivity and Their Application in Gene Delivery

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