One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder

doi:10.6023/cjoc201611009

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (4): 925-935.DOI: 10.6023/cjoc201611009 Previous Articles Next Articles

ARTICLE

铟粉促进下“一锅法”合成三氟甲基高烯丙基酰肼化合物

李军, 杨天宇, 张怀远, 黄丹凤, 王克虎, 苏瀛鹏, 胡雨来

西北师范大学化学化工学院兰州 730070

收稿日期:2016-11-04 修回日期:2016-12-26 发布日期:2017-01-10
通讯作者: 黄丹凤, 胡雨来 E-mail:huyl@nwnu.edu.cn;huangdf@nwnu.edu.cn
基金资助:
国家自然科学基金（Nos.21262031，21462037）资助项目.

One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder

Li Jun, Yang Tianyu, Zhang Huaiyuan, Huang Danfeng, Wang Kehu, Su Yingpeng, Hu Yulai

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received:2016-11-04 Revised:2016-12-26 Published:2017-01-10
Contact: 10.6023/cjoc201611009 E-mail:huyl@nwnu.edu.cn;huangdf@nwnu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21262031, 21462037).

1. One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder.PDF(13094KB)

Abstract

An one-pot reaction of trifluoroacetaldehyde methyl hemiacetal or trifluoroketones, acylhydrazines and allyl bromide promoted by indium powder is reported, and a series of trifluoromethylated homoallylic N-acylhydrazines were obtained with good to excellent yields. The features of this process include readily available starting materials as trifluoromethyl building blocks, mild conditions and easy operation.

Key words: one-pot, indium powder, trifluoroacetaldehyde methyl hemiacetal, trifluoroketones, arylacylhydrazines, trifluoromethylated homoallylic N-acylhydrazines

Cite this article

Li Jun, Yang Tianyu, Zhang Huaiyuan, Huang Danfeng, Wang Kehu, Su Yingpeng, Hu Yulai. One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder[J]. Chin. J. Org. Chem., 2017, 37(4): 925-935.

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铟粉促进下“一锅法”合成三氟甲基高烯丙基酰肼化合物

One-Pot Synthesis of Trifluoromethylated Homoallylic N-Acylhydrazines Promoted by Indium Powder

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