Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (4): 936-942.DOI: 10.6023/cjoc201612006 Previous Articles     Next Articles



吴丽丽, 苏瀛鹏, 种思颖, 张为钢, 黄丹凤, 王克虎, 胡雨来   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2016-12-02 修回日期:2017-01-04 发布日期:2017-01-10
  • 通讯作者: 苏瀛鹏, 胡雨来;
  • 基金资助:


Chiral Thiourea Catalyzed Asymmetric Henry Reaction: Construction of Stereogenic Center Bearing a CF3 Group from 2,2,2-Trifluoroacetophenone Substrates

Wu Lili, Su Yingpeng, Chong Siying, Zhang Weigang, Huang Danfeng, Wang Kehu, Hu Yulai   

  1. a. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2016-12-02 Revised:2017-01-04 Published:2017-01-10
  • Contact: 10.6023/cjoc201612006;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21362033, 21262031).

An asymmetric Henry reaction with 2,2,2-trifluoroacetophenone as trifluoromethyl building block was described. This reaction was catalyzed by bifunctional thiourea derived from quinine to give the product bearing a CF3 stereogenic center in good yield with good enantioselectivity.

Key words: organocatalyst, chiral thiouera, Henry reaction, 2,2,2-trifluoroacetophenone