Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1514-1528.DOI: 10.6023/cjoc201908030 Previous Articles     Next Articles


张永娜, 段慧欣, 汪游清   

  1. 河南大学化学化工学院 河南省多酸化学重点实验室 河南省天然药物与免疫工程重点实验室 河南开封 475004
  • 收稿日期:2019-08-22 修回日期:2019-11-01 发布日期:2020-03-04
  • 通讯作者: 张永娜, 汪游清;
  • 基金资助:

Research Progress in Asymmetric Reactions of Imines Using Chiral Primary Amines as Organocatalysts

Zhang Yongna, Duan Hui-Xin, Wang You-Qing   

  1. College of Chemistry and Chemical Engineering, Henan Key Laboratory of Polyoxometalate Chemistry, Provincial Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, Henan 475004
  • Received:2019-08-22 Revised:2019-11-01 Published:2020-03-04
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. U1404211), and the Key Scientific and Technological Research Projects of Henan Education Department (No. 14A150029).

Chiral primary amine is a kind of important small organic molecule catalyst in the field of asymmetric organocatalysis. Like secondary amine catalyst, primary amine can react with carbonyl compounds to form reactive intermediate of enamine or iminium to catalyze various asymmetric reactions, achieving excellent enantioselectivities. The catalytic asymmetric 1,2-addition to the electrophilic C=N double bond of imines (involving imine intermediates in the reaction process) is the most efficient way to obtain nitrogen-containing compounds bearing α-chiral center. In recent years, the highly enantioselective asymmetric reaction of imines by chiral primary amine catalysts has made some progress, so this topic is summarized and prospected.

Key words: chirality, primary amines, imines, asymmetric catalysis, organocatalysts