Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1824-1829.DOI: 10.6023/cjoc201612032 Previous Articles     Next Articles



张志国, 郑丹, 麻娜娜, 毕晶晶   

  1. 河南师范大学化学化工学院 新乡 453007
  • 收稿日期:2016-12-08 修回日期:2017-01-19 发布日期:2017-03-03
  • 通讯作者: 张志国
  • 基金资助:


Brønsted Acid-Promoted the Synthesis of Furo[2,3-b]quinolines

Zhang Zhiguo, Zheng Dan, Ma Na'na, Bi Jingjing   

  1. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007
  • Received:2016-12-08 Revised:2017-01-19 Published:2017-03-03
  • Contact: 10.6023/cjoc201612032
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21272057,21372065),the Young Backbone Teachers Fund of Henan Province (No.2014GGJS-049),the Key Project of Henan Provincal Educational Committee (Nos.14A150019,14B150042,15A150015),the Science&Technology Innovation Talents in Universities of Henan Province (No.17HASTIT002),and the Outstanding Young Talent Cultivation Project Funding of Henan Normal University (No.14YR002).

The furoquinoline unit is present in many natural products. Here, an approach is presented for the preparing of furo[2,3-b]quinolines from readily available multi-substituted furans in the presence of Brønsted acid via an intramolecular cyclization under the heating conditions. Simple operation, good compatibility, high regioselectivity and morderate yields are the advantages of the method.

Key words: Brø, nsted acid, furo[2,3-b]quinoline, trifluoromethanesulfonic acid, Friedel-Crafts reaction