Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (6): 1537-1541.DOI: 10.6023/cjoc201701009 Previous Articles     Next Articles



昝宁宁, 万福贤, 王士春, 张君辉, 姜林   

  1. 山东农业大学化学与材料科学学院 泰安 271018
  • 收稿日期:2017-01-04 修回日期:2017-02-12 发布日期:2017-02-27
  • 通讯作者: 姜林
  • 基金资助:


Synthesis and Biological Activity of Novel 3-Phenylpropan-1-one Oxime Ethers Containing Pyridine Moiety

Zan Ningning, Wan Fuxian, Wang Shichun, Zhang Junhui, Jiang Lin   

  1. College of Chemistry and Material Science, Shandong Agricultural University, Taian 271018
  • Received:2017-01-04 Revised:2017-02-12 Published:2017-02-27
  • Contact: 10.6023/cjoc201701009
  • Supported by:

    Project supported by the Natural Science Foundation of Shandong Province (No. ZR2014BM030).

To search for the pyridine pesticide lead compound with high antigungal activity, a series of novel 3-phenyl propan-1-one oxime ethers bearing pyridine moiety were synthesized using 3-acetypyridine, benzaldehyde, substituted anilines and alkoxyamine hydrochlorides as starting materials. The structures of target compounds were determined by IR, 1H NMR, 13C NMR and elemental analysis. Meanwhile, the target compounds were evaluated for their antifungal activities against S. sclerotiorum and B. cinerea by the mycelium growth rate method. The results indicated that some compounds displayed high antifungal activity to the two kinds of pathogenic fungi, and their activities were even higher than that of the positive control, chlorothalonil.

Key words: heterocycles, pyridine, ketones, oxime ethers, biological activitity