Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (10): 2590-2608.DOI: 10.6023/cjoc201702041 Previous Articles     Next Articles



王翱a,b, 肖永龙b, 周宇b, 徐进宜a, 柳红b   

  1. a 中国药科大学 天然药物活性物质与功能国家重点实验室 南京 210000;
    b 中国科学院上海药物研究所 受体结构与功能重点实验室 上海 201203
  • 收稿日期:2017-02-26 修回日期:2017-05-25 发布日期:2017-06-02
  • 通讯作者: 周宇, 柳红;
  • 基金资助:


Progress of Organic Reactions Catalyzed by N-Heterocyclic Carbenes

Wang Aoa,b, Xiao Yonglongb, Zhou Yub, Xu Jinyia, Liu Hongb   

  1. a State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210000;
    b CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203
  • Received:2017-02-26 Revised:2017-05-25 Published:2017-06-02
  • Contact: 10.6023/cjoc201702041;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21632008).

Since the first stable N-heterocyclic carbene was isolated by Arduengo in 1991, N-heterocyclic carbine has developed rapidly as a kind of efficient organic catalyst. It plays important role in building complex molecules in organic synthesis for the characteristics of umpolung. Some special Lewis bases and oxidants can induce carbine reaction with carbonyl to form Breslow intermediates, enol and homoenolate, which expand the reaction greatly. In this paper, the recent progresses in organic catalytic reactions including Stetter reaction, a3-d3 umpolung catalyzed by carbines are reviewed.

Key words: N-heterocyclic carbene, organic catalytic, umpolung