Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides

doi:10.6023/cjoc201705031

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (11): 2895-2904.DOI: 10.6023/cjoc201705031 Previous Articles Next Articles

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对羟基苯丙酮酸双加氧酶(HPPD)的结构及其吡唑类除草剂的最新研究进展

何波^a, 王大伟^b, 杨文超^a, 陈琼^a, 杨光富^a,b

a 华中师范大学化学学院农药与化学生物学教育部重点实验室武汉 430079;
b 南开大学化学学院元素有机化学国家重点实验室天津 300071

收稿日期:2017-05-21 修回日期:2017-06-22 发布日期:2017-07-04
通讯作者: 杨光富 E-mail:gfyang@mail.ccnu.edu.cn
基金资助:
国家科技支撑计划（No.2014BAD20B01）、国家自然科学资金基金（Nos.21372093，21672079）及中国高校基本科研业务费（No.CCNU15A02011）资助项目.

Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides

He Bo^a, Wang Dawei^b, Yang Wenchao^a, Chen Qiong^a, Yang Guangfu^a,b

a Key Laboratory of Pesticide and Chemical Biology, College of Chemistry, Central China Normal University, Wuhan 430079;
b State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071

Received:2017-05-21 Revised:2017-06-22 Published:2017-07-04
Contact: 10.6023/cjoc201705031 E-mail:gfyang@mail.ccnu.edu.cn
Supported by:
Project supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology (No. 2014BAD20B01), the National Natural Science Foundation of China (No. 21372093, 21672079) and the Chinese Universities Basic Scientific Research (No. CCNU15A02011).

4-Hydroxyphenylpyruvate dioxygenase (HPPD), a target for green herbicide discovery, has recently attracted a large number of famous scientists attention owing to controlling efficacy of resistant weeds. The structures of HPPD, inhibitors binding sites, mode of action and their metabolites are summarized. The current commercial and developing pyrazole-containing herbicides of HPPD are analyzed. Based on combining theory and practical application, a direction to find or design a new inhibitor is also oriented.

Key words: 4-hydroxyphenylpyruvate dioxygenase, mode of action, binding site, herbicide

Cite this article

He Bo, Wang Dawei, Yang Wenchao, Chen Qiong, Yang Guangfu. Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides[J]. Chin. J. Org. Chem., 2017, 37(11): 2895-2904.

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对羟基苯丙酮酸双加氧酶(HPPD)的结构及其吡唑类除草剂的最新研究进展

Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides

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