Design, Synthesis and Bioactivity of Novel 2-Aroyl-5-alkylcyclopentanone Derivatives

doi:10.6023/cjoc201208029

Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 143-147.DOI: 10.6023/cjoc201208029 Previous Articles Next Articles

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新型2-取代苯甲酰基-5-烷基环戊酮的设计、合成与生物活性研究

徐海珍^a, 朱有全^b, 谢丽芬^b, 王晓芳^b

a 天津师范大学化学学院天津 300387;
b 南开大学元素有机化学国家重点实验室天津 300071

收稿日期:2012-08-28 修回日期:2012-09-22 发布日期:2012-09-26
通讯作者: 徐海珍, 朱有全 E-mail:hxxyxhz@mail.tjnu.edu.cn;zyq8165@nankai.edu.cn
基金资助:
国家973计划(No. 2010CB126103);国家自然科学基金(Nos. 20772066, 21072108)和“十二五”科技支撑计划(No. 2011BAE06B05-3)资助项目.

Design, Synthesis and Bioactivity of Novel 2-Aroyl-5-alkylcyclopentanone Derivatives

Xu Haizhen^a, Zhu Youquan^b, Xie Lifen^b, Wang Xiaofang^b

a College of Chemistry, Tianjin Normal University, Tianjin 300387;
b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071

Received:2012-08-28 Revised:2012-09-22 Published:2012-09-26
Supported by:
Project support by the National Basic Research Program of China (973 Program) (No. 2010CB126103), the National Natural Science Foundation of China (Nos. 20772066, 21072108) and the National Key Technologies R&D Program (No. 2011BAE06B05-3).

To find new lead compounds with muti-bioactivities, a series of novel 2-aroyl-5-alkylcyclopentanone derivatives containing 2-bezoylenthenol were designed on the base of various commercial products. The target compounds were synthesized from diethyl adipate in 6 steps. Their structures were confirmed by IR, ¹H NMR spectra, X-ray and elemental analysis or HRMS. The preliminary bioassay results indicated that some compounds showed obvious inhibition effects against Brassica campestris, and the herbicidal activities were more than 60% at 100 μg/mL.

Key words: 4-hydroxyphenylpyruvate dioxygenase, 2-bezoylenthenol, cyclopropanone, herbicidal activity

Cite this article

Xu Haizhen, Zhu Youquan, Xie Lifen, Wang Xiaofang. Design, Synthesis and Bioactivity of Novel 2-Aroyl-5-alkylcyclopentanone Derivatives[J]. Chin. J. Org. Chem., 2013, 33(01): 143-147.

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新型2-取代苯甲酰基-5-烷基环戊酮的设计、合成与生物活性研究

Design, Synthesis and Bioactivity of Novel 2-Aroyl-5-alkylcyclopentanone Derivatives

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