Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 183-189.DOI: 10.6023/cjoc201706025 Previous Articles     Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑

Articles

基于异斯特维醇的新型伯胺-方酰胺催化的高对映选择性Michael加成反应

马志伟a, 刘晓锋b, 刘俊桃a, 陶京朝b   

  1. a 河南牧业经济学院基础课教研部 郑州 450000;
    b 郑州大学化学与分子工程学院 郑州 450000
  • 收稿日期:2017-06-19 修回日期:2017-09-21 出版日期:2018-01-25 发布日期:2017-10-11
  • 通讯作者: 马志伟, 陶京朝 E-mail:zwma@hnuahe.edu.cn;jctao@zzu.edu.cn
  • 基金资助:

    河南省教育厅科学技术研究重点(No.15A150049)资助项目.

Highly Enantioselective Michael Addition Catalyzed by New Primary Amine-Squaramide Organocatalysts

Ma Zhiweia, Liu Xiaofengb, Liu Juntaoa, Tao Jingchaob   

  1. a Department of Fundamental Courses, Henan University of Animal Husbandry and Economy, Zhengzhou 450000;
    b College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450000
  • Received:2017-06-19 Revised:2017-09-21 Online:2018-01-25 Published:2017-10-11
  • Contact: 10.6023/cjoc201706025 E-mail:zwma@hnuahe.edu.cn;jctao@zzu.edu.cn
  • Supported by:

    Project supported by the Key Project of Colleges and Universities of Henan Province (No. 15A150049).

The asymmetric Michael addition reaction of α,α-disubstituted aldehydes to maleimides catalyzed by new bifunctional primary amine-squaramides has been developed. This organocatalytic asymmetric reaction provides easy access to functionalized succinimides with a broad substrate scope. Both enantiomers of desired succinimide derivatives were obtained in good to excellent yields (up to 98%) with excellent enantioselectivities (up to >99% ee )

Key words: primary amine-squaramide, organocatalysis, Michael addition, aldehyde, maleimide, succinimide derivative