Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 215-220.DOI: 10.6023/cjoc201708009 Previous Articles     Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑 元素有机化学合辑2018-2019



于文全, 常俊标   

  1. 郑州大学化学与分子工程学院 郑州 450001
  • 收稿日期:2017-08-06 修回日期:2017-08-31 发布日期:2017-09-15
  • 通讯作者: 常俊标
  • 基金资助:


I2/CuI-Mediated Oxidative Cyclization of Enamides to Polysubstituted Oxazoles

Yu Wenquan, Chang Junbiao   

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
  • Received:2017-08-06 Revised:2017-08-31 Published:2017-09-15
  • Contact: 10.6023/cjoc201708009
  • Supported by:

    Project supported by the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004) and the National Natural Science Foundation of China (No. 81330075).

A concise and efficient iodine/copper(I) iodide-mediated intramolecular oxidative C—O bond formation reaction has been developed for oxazole synthesis. Under the optimal reaction conditions, oxidative cyclization of readily accessible enamide substrates provides facile access to a variety of oxazole derivatives bearing aryl, alkyl, amide, ester, and acyl substituents.

Key words: iodine, copper(I) iodide, oxidative cyclization, enamides, oxazoles