Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 259-265.DOI: 10.6023/cjoc201708036 Previous Articles     Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑



王涛, 许凯, 张安安, 王万里, 刘澜涛   

  1. 商丘师范学院化学化工学院 药物绿色合成河南省工程实验室 商丘 476000;商丘师范学院化学化工学院 河南省生物分子识别与传感重点实验室 商丘 476000
  • 收稿日期:2017-08-18 修回日期:2017-10-05 发布日期:2017-10-16
  • 通讯作者: 王涛, 刘澜涛;
  • 基金资助:


Buchwald-Hartwig Amination of Aryl Chlorides Catalyzed by Trinuclear N-Heterocyclic Carbene-Palladium(Ⅱ) Complexes

Wang Tao, Xu Kai, Zhang An'an, Wang Wanli, Liu Lantao   

  1. Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000;Henan Key Laboratory of Biomolecular Recognition and Sensing, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000
  • Received:2017-08-18 Revised:2017-10-05 Published:2017-10-16
  • Contact: 10.6023/cjoc201708036;
  • Supported by:

    Project supported by the National Natural Sciences Foundation of China (Nos. U1404205, 21572126 and 21202095), the Program for Science & Technology Innovation Talents in Universities of Henan Province (No. 14HASTIT016), Innovation Scientists and Technicians Troop Construction Projects of Henan Province, and Key Scientific and Technological Project of Henan Province (152102410056).

The trinuclear N-heterocyclic carbene-palladium(Ⅱ) complexes were found to be the effective catalyst precursors for the Buchwald-Hartwig amination of aryl chlorides. With catalyst loading of 2.0 mol%, the amination of secondary and primary amines with a variety of electronically and structurally diverse aryl chlorides gave the desired products in moderate to excellent yields within hours.

Key words: N-heterocyclic carbene, trinuclear palladium complexes, Buchwald-Hartwig amination, aryl chlorides