Novel Pd-N-Heterocyclic Carbene Complexes: Design, Synthesis and Applyment in Buchwald-Hartwig Cross Coupling Reaction

doi:10.6023/cjoc201610012

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (8): 2050-2056.DOI: 10.6023/cjoc201610012 Previous Articles Next Articles

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新型氮杂环卡宾-钯配合物的设计、制备及在Buchwald-Hartwig交叉偶联反应中的应用

王凡, 胡宇才, 沈安, 曹育才

上海化工研究院上海市聚烯烃催化技术重点实验室聚烯烃催化技术与高性能材料国家重点实验室上海 200062

收稿日期:2016-12-26 修回日期:2017-01-22 发布日期:2017-04-13
通讯作者: 沈安, 曹育才 E-mail:caoyc@srici.cn;shenan_cn@126.com
基金资助:
上海市科委青年科技启明星计划（No.15QB1401700）资助项目.

Novel Pd-N-Heterocyclic Carbene Complexes: Design, Synthesis and Applyment in Buchwald-Hartwig Cross Coupling Reaction

Wang Fan, Hu Yucai, Shen An, Cao Yucai

State Key Laboratory of Polyolefins and Catalysis, Shanghai Key Laboratory of Catalysis Technology for Polyolefins, Shanghai Research Institute of Chemical Industry, Shanghai 200062

Received:2016-12-26 Revised:2017-01-22 Published:2017-04-13
Contact: 10.6023/cjoc201610012 E-mail:caoyc@srici.cn;shenan_cn@126.com
Supported by:
Project supported by the Science and Technology Commission of Shanghai Municipality (No. 15QB1401700).

1. Novel Pd-N-Heterocyclic Carbene Complexes: Design, Synthesis and Applyment in Buchwald-Hartwig Cross Coupling Reaction.PDF(2001KB)

Abstract

N-Heterocyclic carbene (NHC) palladium complexes with different imine ligands have been developed and applied in Buchwald-Hartwig cross coupling reaction. The structure of imine ligand would influence the catalytic activity apparently. Especially, the imine ligand with electron withdrawing group performed best. Low to 0.5 mol% catalyst loading could realize effective Buchwald-Hartwig cross coupling reaction between various aryl chlorides and amines.

Key words: N-heterocyclic carbene, palladium complexes, Buchwald-Hartwig cross coupling reaction

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Wang Fan, Hu Yucai, Shen An, Cao Yucai. Novel Pd-N-Heterocyclic Carbene Complexes: Design, Synthesis and Applyment in Buchwald-Hartwig Cross Coupling Reaction[J]. Chin. J. Org. Chem., 2017, 37(8): 2050-2056.

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新型氮杂环卡宾-钯配合物的设计、制备及在Buchwald-Hartwig交叉偶联反应中的应用

Novel Pd-N-Heterocyclic Carbene Complexes: Design, Synthesis and Applyment in Buchwald-Hartwig Cross Coupling Reaction

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