Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 2028-2035.DOI: 10.6023/cjoc201803036 Previous Articles     Next Articles



章吕烨, 吴彬强, 陈张涛, 胡锦锦, 曾晓飞, 钟国富   

  1. 杭州师范大学材料与化学化工学院 杭州 310036
  • 收稿日期:2018-03-23 修回日期:2018-05-03 发布日期:2018-05-14
  • 通讯作者: 曾晓飞, 钟国富;
  • 基金资助:


Synthesis of 2,3'-Bisindole Derivatives Catalyzed by TfOH

Zhang Lüye, Wu Binqiang, Chen Zhangtao, Hu Jinjin, Zeng Xiaofei, Zhong Guofu   

  1. College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036
  • Received:2018-03-23 Revised:2018-05-03 Published:2018-05-14
  • Contact: 10.6023/cjoc201803036;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21672048), the Natural Science Foundation of Zhejiang Province (No. LY18B020015).

A highly efficient TfOH-catalyzed addition of C3-substituted indole derivatives with (1H-indol-2-yl)diphenyl-methanols has been established, leading to the synthesis of a series of potentially bioactive 2,3'-bisindols in moderate to high yields (48%~89%) and with broad substrate scope under mild conditions. In addition, the furan-2-yldiphenylmethanol could also be applied in the reaction and afforded 2-(5-benzhydrylfuran-2-yl)-1H-indole in good yield.

Key words: addition reaction, synthetic method, 2,3'-bisindole derivatives, (1H-indol-2-yl)diphenylmethanol, TfOH