Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (4): 1101-1110.DOI: 10.6023/cjoc202111032 Previous Articles     Next Articles



刘文启a, 沈振陆a,*(), 徐森苗b,*()   

  1. a 浙江工业大学化学工程学院 杭州 310014
    b 中国科学院兰州化学物理研究所 羰基合成与选择氧化国家重点实验室 兰州 730000
  • 收稿日期:2021-11-23 修回日期:2021-12-08 发布日期:2021-12-15
  • 通讯作者: 沈振陆, 徐森苗
  • 基金资助:
    国家自然科学基金(91956116); 国家自然科学基金(21776260)

Synthesis of 1,1-Diboron Alkanes via Diborylation of Unactivated Primary C(sp3)—H Bonds Enabled by AsPh3/Iridium Catalysis

Wenqi Liua, Zhenlu Shena(), Senmiao Xub()   

  1. a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
    b State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences, Lanzhou 730000
  • Received:2021-11-23 Revised:2021-12-08 Published:2021-12-15
  • Contact: Zhenlu Shen, Senmiao Xu
  • Supported by:
    National Natural Science Foundation of China(91956116); National Natural Science Foundation of China(21776260)

The AsPh3/iridium catalyzed diborylation of unactivated primary C(sp3)—H bonds using pyrazoles as directing groups was disclosed. This method could tolerate a variety of functional groups, affording a vast array of 1,1-diboron alkanes in moderate to good yields. The synthetic utility of the current method on a gram-scale reaction for further functionalization was also demonstrated.

Key words: C—H borylation, organoboron, synthetic methods, iridium