Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2435-2442.DOI: 10.6023/cjoc201804012 Previous Articles     Next Articles

Special Issue: 合成科学



张学文a, 李鹏飞b, 袁宇a, 贾晓东a   

  1. a 扬州大学化学化工学院 扬州 225002;
    b 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2018-04-08 修回日期:2018-05-17 发布日期:2018-06-01
  • 通讯作者: 袁宇, 贾晓东;
  • 基金资助:


Synthesis of Quinoline Derivatives Containing Lactone Structure Promoted by Radical Cation Salt

Zhang Xuewena, Li Pengfeib, Yuan Yua, Jia Xiaodonga   

  1. a School of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002;
    b College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2018-04-08 Revised:2018-05-17 Published:2018-06-01
  • Contact: 10.6023/cjoc201804012;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 1362030, 21562038).

Using aniline derivatives containing lactone structure and styrenes as the starting materials, a series of lactone substituted quinolines were constructed efficiently by oxidative Povarov reaction, promoted by radical cation salt. This reaction provides a new method to achieve the construction of functionalized quinoline skeletons. The mechanistic study reveales that the oxidation of the saturated C-H bond is mediated by free radical intermediate.

Key words: radical cation salt, C-H activation, Povarov reaction, quinoline, lactone