Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2443-2449.DOI: 10.6023/cjoc201802017 Previous Articles     Next Articles

Special Issue: 合成科学


Hydramicromelins A,B和C母核的对映选择性合成

孙默然a,b, 代磊a,b, 杨华a,b, 刘宏民a,b, 于德泉a   

  1. a 郑州大学药学院 郑州 450001;
    b 新药创制与药物安全性评价河南省协同创新中心 郑州 450001
  • 收稿日期:2018-02-09 修回日期:2018-03-28 发布日期:2018-04-27
  • 通讯作者: 杨华, 刘宏民;
  • 基金资助:


Enantioselective Synthesis of Core Structures of Hydramicromelins A, B and C

Sun Morana,b, Dai Leia,b, Yang Huaa,b, Liu Hongmina,b, Yu Dequana   

  1. a School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001;
    b Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001
  • Received:2018-02-09 Revised:2018-03-28 Published:2018-04-27
  • Contact: 10.6023/cjoc201802017;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21372205, 21302175) and the Basic Research Project of Science and Technology Department of Henan Province (No. 132300410028).

Hydramicromelins A~C are coumarin compounds with unique chemical structure and biological activity. With[2,3]-Meisenheimer rearrangemen as a key reaction which has been developed in our laboratory, the core structures of Hydramicromelin A, B and C were synthesized from L-phenylglycine. The route included Wittig reaction,[2,3]-Meisenheimer rearrangement, epoxidation and dihydroxylation reaction, and it was high-yield and high-enantioselectivity.

Key words: hydramicromelins A, B and C, [2,3]-Meisenheimer rearrangement, chiral tertiary alcohol, epoxidation