Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (11): 3137-3140.DOI: 10.6023/cjoc201804028 Previous Articles     Next Articles



刘艳萍a,b, 张项林a,b, 牛海渊a,b, 官春艳a,b, 孙福康a,b, 杨柳萌c, 付艳辉a,b   

  1. a 海南师范大学 热带药用植物化学教育部重点实验室 海口 571158;
    b 海南师范大学 南药资源产业化关键技术研究海口市重点实验室 海口 571158;
    c 中国科学院昆明动物研究所 中国科学院动物模型与人类疾病机理重点实验室 昆明 650223
  • 收稿日期:2018-04-15 修回日期:2018-06-03 发布日期:2018-06-29
  • 通讯作者: 付艳辉
  • 基金资助:


A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus

Liu Yanpinga,b, Zhang Xianglina,b, Niu Haiyuana,b, Guan Chunyana,b, Sun Fukanga,b, Yang Liumengc, Fu Yanhuia,b   

  1. a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158;
    b Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158;
    c Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223
  • Received:2018-04-15 Revised:2018-06-03 Published:2018-06-29
  • Supported by:

    Project supported by the Key Research and Development Project of Hainan Province (No. ZDYF2016221), the Key Research and Development Project of Haikou City (No. 2017050), the National Natural Science Foundation of China (Nos. 21662011, 31660097) and the Program for Innovative Research Team in University (No. IRT-16R19).

A new stemodane diterpenoid, trigoheterone A (1), together with seven known diterpenoids, was isolated from the stems and leaves of Trigonostemon heterophyllus. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from the genus Trigonostemon for the first time. The cytotoxicities of all isolated compounds were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). As a result, eight compounds exhibited significant inhibitory effects with IC50 values comparable to those of cisplatin.

Key words: Trigonostemon, Trigonostemon heterophyllus, stemodane diterpenoid, cytotoxicities