Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (10): 2763-2766.DOI: 10.6023/cjoc201705035 Previous Articles     Next Articles

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海南暗罗根克罗烷型二萜化学成分研究

李小宝a, 陈光英a, 邵泰明a,b, 宋小平a, 韩长日a,b, 余章昕a   

  1. a 海南师范大学化学与化工学院 热带药用植物化学教育部重点实验室 海口 571158;
    b 海南省药食同源植物资源重点实验室 海南科技职业学院化学与材料工程学院 海口 571126
  • 收稿日期:2017-05-23 修回日期:2017-06-10 发布日期:2017-06-23
  • 通讯作者: 韩长日 E-mail:hchr116@126.com
  • 基金资助:

    国家自然科学基金(Nos.81160391,21362009,81360478)、国家国际科技合作专项(No.2014DFA40850)、创新发展团队(No.IRT-16R19)、海南省自然科学基金创新研究团队(No.2016CXTD007)及海南省自然科学基金(No.20162031)资助项目.

Clerodane Diterpenes from the Roots of Polyalthia laui

Li Xiaobaoa, Chen Guangyinga, Shao Taimingaa,b, Song Xiaopinga, Han Changria,b, Yu Zhangxina   

  1. a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158;
    b Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou 571126
  • Received:2017-05-23 Revised:2017-06-10 Published:2017-06-23
  • Contact: 10.6023/cjoc201705035 E-mail:hchr116@126.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.81160391,21362009,81360478),the International S&T Cooperation Program of China (No.2014DFA40850),the Program for Innovative Research Team in University (No.IRT-16R19),the Hainan Provincal Natural Science Foundation of Innovatie Research Team Project (No.2016CXTD007) and the Natural Science Foundation of Hainan Province (No.20162031).

Five clerodane diterpenes were isolated from the roots of Polyalthia laui during a systematic phytochemical investigation. Their structures were elucidated by the NMR and HRMS data as methyl (4→2)-abeo-2,13-diformyl-cleroda-2,12E-dien-15-ate (1), (E)-ent-cleroda-3,12-diene-15,16-dioic acid (2), 14,15-dinorclerod-3-ene-2,13-dione (3), solidagolactone (4), and 16-hydroxy-3,13Z-kolavadien-16,15-olide (5). Among them, compounds 1~2 are new clerodane diterpenes. Biological evaluation of compounds 1~5 against human Hela, A549, MCF-7 and HL-60 human cancer cell lines showed that all com-pounds displayed moderate cytotoxicities against various human cancer cell lines with IC50 ranged from 13.22 to 37.16 μmol/L.

Key words: Polyalthia laui, clerodane diterpenes, cytotoxicities