Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (4): 1187-1192.DOI: 10.6023/cjoc201808011 Previous Articles     Next Articles

Notes

Se粉为原料的芳硒基取代黄酮衍生物的合成

冯春来, 朱杰, 唐秋洁, 周爱华   

  1. 江苏大学药学院 镇江 212013
  • 收稿日期:2018-08-10 修回日期:2018-09-20 出版日期:2019-04-25 发布日期:2018-11-12
  • 通讯作者: 周爱华 E-mail:ahz@ujs.edn.cn
  • 基金资助:

    江苏大学(No.1281290006)资助项目.

Synthesis of ArSe-Substituted Flavone Derivatives Using Se Powder

Feng Chunlai, Zhu Jie, Tang Qiujie, Zhou Aihua   

  1. Pharmacy School, Jiangsu University, Zhenjiang 212013
  • Received:2018-08-10 Revised:2018-09-20 Online:2019-04-25 Published:2018-11-12
  • Contact: 10.6023/cjoc201808011 E-mail:ahz@ujs.edn.cn
  • Supported by:

    Project supported by Jiangsu University (No. 1281290006).

New flavone derivatives are highly valued in drug discovery due to their diversity of important bioactivities. Herein, one simple Cu-catalyzed method of constructing C-Se bonds on flavone structures using convenient Se powder via C-H functionalization is reported, regioselectively affording ArSe-substituted flavone derivatives in good yields.

Key words: selenium, C—Se bond, flavone, selenide, C—H functionalization