Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3338-3352.DOI: 10.6023/cjoc201904068 Previous Articles     Next Articles

无过渡金属催化的咪唑并杂环C—H键的C—杂原子化的研究进展

徐鑫明a, 陈德茂b,c, 王祖利b   

  1. a 烟台大学化学化工学院 山东烟台 264005;
    b 青岛农业大学化学与药学院 山东青岛 266109;
    c 湖南科技大学化学化工学院 湖南湘潭 411201
  • 收稿日期:2019-04-27 修回日期:2019-07-24 出版日期:2019-12-25 发布日期:2019-08-30
  • 通讯作者: 徐鑫明 E-mail:xin_mingxu@163.com
  • 基金资助:
    烟台大学青年博士基金(No.HY19B06)资助项目.

Recent Progress in Transition Metal-Free C-Heteroatom Bond Formation by Functionalization of C-H Bond in Imidazole-Fused Heterocycles

Xu Xinminga, Chen Demaob,c, Wang Zulib   

  1. a College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005;
    b College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, Shandong 266109;
    c School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201
  • Received:2019-04-27 Revised:2019-07-24 Online:2019-12-25 Published:2019-08-30
  • Supported by:
    Project supported by the Young Scholars Research Fund of Yantai University (Nos. HY19B06).

Recently, the direct incorporation of heteroatom into imidazole-fused heterocycles through transition metal-free C-H functionalization has rapidly been advanced and become an eco-friendly synthetic tool for the synthesis of functionalized natural or bioactive molecules such as (hetero)arenes, olefins, carbonyl compounds. In particular, the C-H functionalization of imidazole-fused heterocycles has been considered to be the most important since it can lead to a new class of biologically active compounds. The recent progress in the incorporation of heteroatom into imidazole-fused heterocycles through transition metal-free C-H functionalization is introduced, and their mechanisms from a new perspective are also elaborated.

Key words: heteroatom, imidazole-fused heterocycles, transition metal-free, reaction mechanism