Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (9): 3067-3077.DOI: 10.6023/cjoc202303041 Previous Articles     Next Articles


李焕清, 陈兆华, 陈祖佳, 邱琪雯, 张又才, 陈思鸿*(), 汪朝阳*()   

  1. 华南师范大学化学学院 教育部环境理论化学重点实验室 广州市生物医学分析化学重点实验室 GDMPA手性药物过程控制与质量评价重点实验室 广州 510006
  • 收稿日期:2023-03-28 修回日期:2023-05-01 发布日期:2023-05-29
  • 基金资助:

Research Progress in Mercury Ion Fluorescence Probes Based on Organic Small Molecules

Huanqing Li, Zhaohua Chen, Zujia Chen, Qiwen Qiu, Youcai Zhang, Sihong Chen(), Zhaoyang Wang()   

  1. Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education; Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine; GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, School of Chemistry, South China Normal University, Guangzhou 510006
  • Received:2023-03-28 Revised:2023-05-01 Published:2023-05-29
  • Contact: E-mail:;
  • Supported by:
    Guangdong Basic and Applied Basic Research Foundation(2021A1515012342)

Mercury has strong biological toxicity and poses great harm to human health and the environment. Fluorescent probes have been widely applied in the detection of mercury ion in recent years, due to these probes with high sensitivity, high selectivity, and real-time monitoring. Owing to the advantages of small molecules such as structural diversity, good repeatability, easy modification, and clear sensing mechanisms, many organic small molecular fluorescence probes for detecting mercury ion have also been developed. According to the different reaction mechanisms between probes and mercury ion, these organic small molecular fluorescence probes can be classified into two categories based on coordination type reactions and bond breaking type reactions. The research progress of organic small molecular fluorescence probes used to detect mercury ion in the past five years is summarized in detail. This provides a reference for their further development in the future, especially for the new turn-on type reactive organic small molecular fluorescence probes for detecting mercury ion by utilizing the characteristic reactions.

Key words: mercury ion detection, fluorescent probes, organic small molecules, reaction mechanism, molecular design and synthesis