Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (8): 2311-2316.DOI: 10.6023/cjoc201905007 Previous Articles     Next Articles

Special Issue: 元素有机化学合辑2018-2019 陈茹玉先生诞辰100周年

Notes

五配位氧磷烷分子间配体交换反应-RNA水解和融合过程的化学模型

王珣a, 陈苏a, 吴翊乐a, 王晓宇b, 唐果a, 刘艳a, 许鹏翔a, 高祥b, 赵玉芬a,b,c   

  1. a 厦门大学化学系 厦门 361005;
    b 厦门大学药学院 厦门 361102;
    c 宁波大学新药技术研究院 宁波 315211
  • 收稿日期:2019-03-20 修回日期:2019-04-17 发布日期:2019-06-03
  • 通讯作者: 高祥, 赵玉芬 E-mail:xgao@xmu.edu.cn;yfzhao@xmu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos.21778042,41876072,21772163,41576081)、厦门南方海洋研究中心(No.17GYY002NF02)及中央高校基本科研业务费专项资金(No.20720170069)资助项目.

Intermolecular Ligand Exchange of Penta-oxy Phosphoranes: Potential Chemical Model for RNA Hydrolysis and Fusion

Wang Xuna, Chen Sua, Wu Yilea, Wang Xiaoyub, Tang Guoa, Liu Yana, Xu Pengxianga, Gao Xiangb, Zhao Yufena,b,c   

  1. a Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005;
    b School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102;
    c Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211
  • Received:2019-03-20 Revised:2019-04-17 Published:2019-06-03
  • Contact: 10.6023/cjoc201905007 E-mail:xgao@xmu.edu.cn;yfzhao@xmu.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21778042, 41876072, 21772163, 41576081), the Xiamen Southern Oceanographic Center (No. 17GYY002NF02), and the Fundamental Research Funds for the Central Universities (No. 20720170069).

Penta-coordinated phosphoranes (ab2) with a five-member cycle and three ligands would simultaneously exchange with themselves under base catalysis to form three different penta-oxy phosphoranes with all the combinatorial ligands referred as a3, b3, and a2b. If we consider a3 and b3 as parents, the products obtained from exchange, namely a2b and ab2, could be regarded as the offspring of the first generation, leading to the diversified chemical structures. Thus, these fascinating reactions could be considered as a promising chemical model for studying the unique chemistry of possible penta-coordinated phosphorus intermediates in the process of RNA self-splicing, hydrolysis and fusion for gene transcription and biological information storage.

Key words: phosphorus chemistry, penta-oxy phosphorane, ligand exchange, organic chemical model