Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3051-3064.DOI: 10.6023/cjoc201905024 Previous Articles     Next Articles

Special Issue: 荧光探针-生物传感合辑 有机超分子化学合辑


张继东a*(), 张俊b, 严瞻c, 谢娟平c   

  1. a 安康学院化学化工学院 陕西省富硒食品质量监督检验中心 陕西安康 725000
    b 西北大学化学与材料科学学院 合成与天然功能分子化学教育部重点实验室 西安 710127
    c 安康学院医学院 陕西安康 725000
  • 收稿日期:2019-05-12 发布日期:2019-07-17
  • 通讯作者: 张继东
  • 基金资助:

Recent Progress in Fluorescent Probes for Adenosine Triphosphate Based on Small Organic Molecules

Zhang Jidonga*(), Zhang Junb, Yan Zhanc, Xie Juanpingc   

  1. a Quality Supervision and Inspection Centre of Se-enriched Food of Shaanxi Province, School of Chemistry & Chemical Engineering, Ankang Univerisity, Ankang, Shaanxi 725000
    b Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710127
    c School of Medicine, Ankang Univerisity, Ankang, Shaanxi 725000
  • Received:2019-05-12 Published:2019-07-17
  • Contact: Zhang Jidong
  • Supported by:
    the Youth Foundation of Shaanxi Provincial Science & Technology Department(2019JQ-504);the Major Scientific Research Projects of the Leading Industry of Ankang City(2016AKZDCY002);the Doctor's Initial Funding of Ankang University(2018AYQDZR06);the Key Laboratory of Se-enriched Products Development and Quality Control, Ministry of Agriculture(Se-2018B02);the Shaanxi Provincial Innovation Experiment Program for University Students(201839032)

Adenosine triphosphate (ATP) is a high-energy phosphate compound commonly existing in various living cells, which plays important roles in the biological activities such as energy storage, cell respiration and enzyme catalytic reactions. Therefore, it is very crucial to ATP research in bio-organism. Fluorescence detection techniques has the advantages of convenient operation, good selectivity and high sensitivity, etc. In recent years, the design and synthesis of efficient ATP fluorescence sensors have become a research focus in the fields of biochemistry and analytical chemistry. According to the structure characteristics, ATP fluorescence chemosensors are categorized as Zn(Ⅱ) metal ions as recognition of bonding site type, other metal ions as recognition of bonding site type and electrostatic or hydrogen bond as interaction type. Based on organic small molecule fluorescence sensors, the recent progress in research of ATP fluorescence sensors in molecular design and application is reviewed, and the prospects for their development are discussed.

Key words: fluorescent chemosensor, adenosine triphosphate, biological imaging, small organic molecules