Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (8): 2322-2337.DOI: 10.6023/cjoc202003055 Previous Articles     Next Articles

单氟甲基化反应的研究进展

刘颖杰, 李晨, 孟建萍, 宋冬雪, 刘冰, 许颖   

  1. 哈尔滨商业大学药学院 哈尔滨 150076
  • 收稿日期:2020-03-24 修回日期:2020-04-25 出版日期:2020-08-25 发布日期:2020-05-15
  • 通讯作者: 刘颖杰 E-mail:liuyj691@nenu.edu.cn
  • 基金资助:
    黑龙江省自然科学基金优秀青年(No.YQ2019B004)、哈尔滨商业大学青年创新人才(No.2016QN056)及哈尔滨商业大学青年后备人才(No.2019CX36)资助项目.

Recent Progress in Monofluoromethylation

Liu Yingjie, Li Chen, Meng Jianping, Song Dongxue, Liu Bing, Xu Ying   

  1. School of Pharmacy, Harbin University of Commerce, Harbin 150076
  • Received:2020-03-24 Revised:2020-04-25 Online:2020-08-25 Published:2020-05-15
  • Supported by:
    Project supported by the Outstanding Youth Project of Natural Science Foundation of Heilongjiang Province (No. YQ2019B004) and the Youth Innovation Talent Project of Harbin University of Commerce (No. 2016QN056) and the Youth Reserve Talent Program of Harbin University of Commerce (No. 2019CX36).

Organic fluorides play an indispensable role in medicine, agricultural chemistry and other fields, among them fluoromethyl functional groups have strong lipophilicity, which can greatly improve the pharmacokinetics properties of drug molecules. Therefore, it is of great value to develop various fluorination reactions, especially to introduce monofluoromethyl into molecules in fluorination chemistry. The research progress of the monofluoromethylation of different structural molecules is summarized according to the classification of fluoromethyl reagents, and the possible mechanism of some reactions is discussed.

Key words: organic fluoride, fluoromethyl functional group, fluoromethyl reagent, monofluoromethylation reaction