Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (5): 837-851.DOI: 10.6023/cjoc201311012 Previous Articles     Next Articles



王光祖a, 赫侠平a, 戴建军a, 许华建a,b   

  1. a 合肥工业大学医学工程学院 合肥 230009;
    b 先进功能材料与器件安徽省重点实验室 合肥 230009
  • 收稿日期:2013-11-09 修回日期:2013-12-23 发布日期:2014-01-02
  • 通讯作者: 许华建,戴建军;
  • 基金资助:

    国家自然科学基金(Nos. 21272050,21072040)资助项目.

Recent Advances in Copper-Promoted Trifluoromethylation Reactions

Wang Guangzua, He Xiapinga, Dai Jianjuna, Xu Huajiana,b   

  1. a School of Chemical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009;
    b Key Laboratory of Advanced Functional Materials and Devices, Anhui Province, Hefei 230009
  • Received:2013-11-09 Revised:2013-12-23 Published:2014-01-02
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21272050, 21072040).

Drug molecules that contain trifluoromethyl group can effectively improve their lipophilicity, absorbability and metabolic stability. Thus, considerable attention has been paid to the introduce of trifluoromethyl group into organic molecules. Recently, transition metal-catalyzed trifluoromethylation has been well developed. The cheap and high activity copper catalyst has also been used to access a variety of trifluoromethylation reactions. In this review, we focus the conversion of a number of substrates including halogenated hydrocarbons, boron reagents, C—H compounds, amines and carboxylic acids into the corresponding trifluoromethyl-containing compounds.

Key words: copper-catalyzed, trifluoromethylation, trifluoromethyl reagents