Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (5): 2029-2037.DOI: 10.6023/cjoc202011001 Previous Articles     Next Articles



杨金宇1, 黄丹凤1, 王克虎1, 王君姣1, 苏瀛鹏1, 邓周斌1, 杨天宇1, 胡雨来1,*()   

  1. 1 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2020-11-02 修回日期:2020-12-24 发布日期:2021-02-07
  • 通讯作者: 胡雨来
  • 基金资助:
    国家自然科学基金(21662030); 国家自然科学基金(22061037)

Study on N-Alkylation Reactions of Trifluoromethylated Acylhydrazones

Jinyu Yang1, Danfeng Huang1, Kehu Wang1, Junjiao Wang1, Yingpeng Su1, Zhoubin Deng1, Tianyu Yang1, Yulai Hu1,*()   

  1. 1 College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2020-11-02 Revised:2020-12-24 Published:2021-02-07
  • Contact: Yulai Hu
  • About author:
    * Corresponding author. E-mail:
  • Supported by:
    National Natural Science Foundation of China(21662030); National Natural Science Foundation of China(22061037)

The N-alkylation reaction of trifluoromethylated acylhydrazones was investigated, and a series of N-alkyl trifluoromethyl acylhydrazones were afforded in good yield. Their structures were confirmed by 1H NMR, 13C NMR and HRMS analysis. The strategy has advantages of simple and mild reaction conditions, wide scope of substrates and good yields. This protocol provides an efficient and new method for the synthesis of N-alkyl substituted trifluoromethyl acylhydrazones.

Key words: trifluoromethyl acylhydrazone, halohydrocarbon, α,β-unsaturated ester, N-alkylation