Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (8): 3015-3033.DOI: 10.6023/cjoc202012036 Previous Articles     Next Articles



陈超a,b, 胡晓东b, 王春喜b, 蓝文贤b, 吴小余a,*(), 曹春阳b,*()   

  1. a 上海大学理学院化学系 上海 200444
    b 中国科学院上海有机化学研究所 生命有机化学国家重点实验室 上海 200032
  • 收稿日期:2020-12-22 修回日期:2021-03-12 发布日期:2021-04-29
  • 通讯作者: 吴小余, 曹春阳
  • 基金资助:
    科技部重点研发(2017YFE0108200); 科技部重点研发(2016YFA0502302); 中国科学院战略性先导科技专项(XDB20000000); 国家自然科学基金(21778065); 国家自然科学基金(21807105); 国家自然科学基金(21977110); 国家自然科学基金(91753119)

Structure- and Mechanism-Based Research Progress of Anti-acquired Immune Deficiency Syndrome Drugs

Chao Chena,b, Xiaodong Hub, Chunxi Wangb, Wenxian Lanb, Xiaoyu Wua(), Chunyang Caob()   

  1. a College of Science, Shanghai University, Shanghai 200444
    b State Key Lab of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2020-12-22 Revised:2021-03-12 Published:2021-04-29
  • Contact: Xiaoyu Wu, Chunyang Cao
  • Supported by:
    National Key Research and Development Program of Ministry of Science and Technology(2017YFE0108200); National Key Research and Development Program of Ministry of Science and Technology(2016YFA0502302); Chinese Academy of Sciences Strategic Priority Research Program(XDB20000000); National Natural Science Foundation of China(21778065); National Natural Science Foundation of China(21807105); National Natural Science Foundation of China(21977110); National Natural Science Foundation of China(91753119)

Human immunodeficiency virus (HIV) is a retrovirus that mainly targets immune cells such as CD4+T lymphocytes and macrophages, which eventually leads to acquired immunodeficiency syndrome (AIDS). HIV continues to be a major global public health challenege, having killed almost 33 million lives so far. Since the emergence of antiretroviral therapy (ART), the combination of antiretroviral drugs has transformed HIV-1 infection, once a fatal illness, into a manageable chronic condition. Based on different targets during the virus replication cycle, anti-AIDS drugs in recent years were classified with focus on the mechanism elucidation, current clinical application and future direction.

Key words: antiretroviral drug, human immunodeficiency virus (HIV), acquired immune deficiency syndrome (AIDS), long-acting inhibitor