Chinese Journal of Organic Chemistry 2021, 41(8)

- About the Cover:
  
  Palladium-catalyzed intramolecular Heck tandem cyclization reactions were developed by Li, Wang and Xu on page 3073. In the presence of palladium iodide as a catalyst and 4-(dimethylamino)triphenylphosphine as a ligand, the 3-substituted indoleamide derivatives were converted to bridged N-heterocyclic products in good yields under simple reaction conditions. The tandem reactions are featured by efficient construction of fused ring compounds in one pot and good functional group compatibility.
- About the Cover:
  
  The synthesis of diarylmethyl phosphorus oxides con-taining CN-substituted quaternary stereocenters via 1,6- conjugate addition of P(O)—H compounds to para- quinone methides is reported by Wang, Kan, Ma and Liu on page 3192. The para-quinone methides with diverse substituents at α-position and aryl groups at δ-position are tolerated.
2021, 41(8)

25 August 2021
Previous issue Next issue
Current Issue

REVIEWS ARTICLES NOTES HIGHLIGHTS

REVIEWS

Advances on the Synthesis of Natural Products with Dihydrobenzofuran Skeleton via Oxidative [3+2] Cycloadditions

Jun Zhao, Jian Xiao, Yawen Wang, Yu Peng

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 2933-2945 DOI: 10.6023/cjoc202103048

Abstract( 1113) HTML( 55) PDF(835KB)( 1895 )

Fig. & Tab. | References | Related Articles | Metrics

Progress in Design and Application of Supramolecular Fluorescent Systems Based on Difluoroboron-Dipyrromethene and Macrocyclic Compounds

Jingjing Guo, Minjie Guo

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 2946-2963 DOI: 10.6023/cjoc202103012

Abstract( 789) HTML( 47) PDF(8923KB)( 1196 )

Fig. & Tab. | References | Related Articles | Metrics

Advances in the Synthesis of Phosphorothioate and Phosphinothioate

Chunqi Liu, Lixian Wang, Xinghua Zhang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 2964-2973 DOI: 10.6023/cjoc202104002

Abstract( 1360) HTML( 41) PDF(1012KB)( 1418 )

Fig. & Tab. | References | Related Articles | Metrics

Advances in the Study of Structural Modification and Biological Activities of Ursolic Acid

Gaizhi Liu, Jinxin Li, Lijun Shi, Mengya Liu, Bangrong Cai

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 2974-2989 DOI: 10.6023/cjoc202102032

Abstract( 1159) HTML( 54) PDF(824KB)( 1450 )

Fig. & Tab. | References | Related Articles | Metrics

Advances in Nitrogen-Directed Aromatic Compound ortho-C—H Bond Borylation Catalyzed by Transition Metals

Huanhuan Luo, Na Pei, Jing Zhang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 2990-3001 DOI: 10.6023/cjoc202103013

Abstract( 933) HTML( 39) PDF(825KB)( 1442 )

Fig. & Tab. | References | Related Articles | Metrics

[3,3] Sigmatropic Shifts and Applications of Hydroxylamine Derivatives

Guangyu Zhang, Jiaxi Xu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3002-3014 DOI: 10.6023/cjoc202103022

Abstract( 951) HTML( 17) PDF(1022KB)( 1059 )

Fig. & Tab. | References | Related Articles | Metrics

Structure- and Mechanism-Based Research Progress of Anti-acquired Immune Deficiency Syndrome Drugs

Chao Chen, Xiaodong Hu, Chunxi Wang, Wenxian Lan, Xiaoyu Wu, Chunyang Cao

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3015-3033 DOI: 10.6023/cjoc202012036

Abstract( 1019) HTML( 47) PDF(10813KB)( 1317 )

Fig. & Tab. | References | Related Articles | Metrics

Electrochemical Approaches for Preparation of Tailor-Made Amino Acids

Nana Wang, Jingcheng Xu, Haibo Mei, Hiroki Moriwaki, Kunisuke Izawa, Vadim A. Soloshonok, Jianlin Han

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3034-3049 DOI: 10.6023/cjoc202102043

Abstract( 1541) HTML( 77) PDF(816KB)( 1743 )

Fig. & Tab. | References | Related Articles | Metrics

Research Progress on Aggregation-Induced Delayed Fluorescence in Materials and Devices

Chou Huang, Zhipeng Qiu, Yang Gao, Wen-Cheng Chen, Shaomin Ji, Yanping Huo

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3050-3072 DOI: 10.6023/cjoc202101053

Abstract( 1075) HTML( 45) PDF(1222KB)( 1824 )

Fig. & Tab. | References | Related Articles | Metrics

ARTICLES

Palladium-Catalyzed Tandem Heck Cyclization Reactions to Access the Bridged N-Heterocyclic Compounds

Man Li, Ying Wang, Yunhe Xu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3073-3082 DOI: 10.6023/cjoc202104059

Abstract( 1004) HTML( 21) PDF(705KB)( 689 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Synthesis of 4(3H)-Quinazolinones by Visible-Light-Induced 2-Benzylaminobenzamides

Xinchang Li, Huiru Yang, Zheyao Hu, Xin Jin, Wenyi Zhang, Xunxiang Guo

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3083-3088 DOI: 10.6023/cjoc202104047

Abstract( 618) HTML( 21) PDF(475KB)( 843 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Palladium-Catalyzed Intramolecular Decarboxylative Allylic Amination of Aroyloxycarbamates

Xiaoying Li, Peihe Li, Zheng Wang, Hui Fu, Qipu Dai

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3089-3096 DOI: 10.6023/cjoc202104030

Abstract( 666) HTML( 15) PDF(585KB)( 474 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)

Lijie Yu, Bo Feng, Zhijia Wang, Lixin Gao, Chun Zhang, Rajendran Satheeshkumar, Jia Li, Yubo Zhou, Wenlong Wang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3097-3105 DOI: 10.6023/cjoc202104041

Abstract( 689) HTML( 11) PDF(2241KB)( 675 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Metal-Free-Involved Cascade Cyclization of Unsaturated Amides with Polychloromethanes

Yaxin Ge, Qinqin Yan, Yunfei Tian, Haijun Wang, Chunfang Zhang, Zejiang Li

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3106-3115 DOI: 10.6023/cjoc202102035

Abstract( 723) HTML( 14) PDF(894KB)( 820 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Design, Synthesis and Bioactivity of Fluopyram Derivatives Containing Diamide Moiety

Qingbo Xu, Peibo Liang, Huizhe Lu, Shuhui Jin, Yanhong Dong, Jianjun Zhang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3116-3125 DOI: 10.6023/cjoc202103021

Abstract( 689) HTML( 31) PDF(2670KB)( 1136 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Cascade Cyclization Reaction Initiated by Benzylic Carbocation of Indole: Scope and Mechanistic Insights

Zhongrun Gao, Yuan Wang, Hang Song, Zhengren Xu, Yanxing Jia

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3126-3133 DOI: 10.6023/cjoc202102006

Abstract( 897) HTML( 20) PDF(1064KB)( 760 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Sc(OTf)₃-Catalyzed 1,6-Conjugate Addition of Thiols to δ-CF₃-δ-aryl-disubstituted para-Quinone Methides: Efficient Construction of Diarylmethane Thioethers

Hua Li, Jingxiang Pang, Huazheng Liu, Changyin Zhao, Song Li, Hengshan Wang, Xigong Liu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3134-3143 DOI: 10.6023/cjoc202103042

Abstract( 624) HTML( 18) PDF(546KB)( 796 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

t-BuOK-Mediated Reductive Desulfonylation/Dehydrogenation for the Synthesis of 2-Substituted 1,3-Dienes and Their [4+2] Cycloaddition Reactions

Jiabing Sun, Tao Miao, Pinhua Li, Lei Wang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3144-3156 DOI: 10.6023/cjoc202102025

Abstract( 880) HTML( 9) PDF(601KB)( 1007 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Synthesis and Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitory Activity Evaluation of Novel Arylaminoacetylhydrazone Derivatives Containing Carbazole Moiety

Yingjun Li, Ledi Lin, Kun Jin, Lixin Gao, Li Sheng, Jihong Liu, Jia Li

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3157-3170 DOI: 10.6023/cjoc202102046

Abstract( 665) HTML( 9) PDF(3280KB)( 746 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Rh(III)-Catalyzed [4+2] Annulation of Indoles with Sulfoxonium Ylides for the Synthesis of Dihydropyrimidoindolone Derivatives

Sai Shu, Zhibin Huang, Yujie Chen, Shan Yang, Yaqiqi Jiang, jingyu Zhang, Yingsheng Zhao

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3171-3179 DOI: 10.6023/cjoc202103027

Abstract( 544) HTML( 11) PDF(566KB)( 668 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Three-Component Reaction for Efficient Synthesis of Functionalized Spiro[cyclopentane-1,3'-indolines]

Weiqing Ma, Ying Han, Jin Sun, Chaoguo Yan

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3180-3191 DOI: 10.6023/cjoc202103034

Abstract( 716) HTML( 8) PDF(655KB)( 602 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

NaO^tBu-Catalyzed Hydrophosphonylation of δ-CN-δ-aryl-disubstituted para-Quinone Methides with Phosphine Oxides

Donglin Wang, Linglong Kan, Yudao Ma, Lei Liu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3192-3203 DOI: 10.6023/cjoc202104003

Abstract( 692) HTML( 19) PDF(649KB)( 827 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)

Zheng Zhang, Chengqiu Dai, Honghong Wu, Jingya Li, Fajun Nan

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3204-3213 DOI: 10.6023/cjoc202103056

Abstract( 520) HTML( 6) PDF(1091KB)( 943 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Synthesis and Antitumor Activity of Amide Derivatives Containing 1,3,4-Thiadiazole and Pyrazole Moieties

Jiaoli Ma, Penghu Guo, Jing Li, Xincheng Liao, Huicheng Cheng

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3214-3222 DOI: 10.6023/cjoc202102030

Abstract( 636) HTML( 14) PDF(624KB)( 652 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Electrochemical 2,2,6,6-tetramethylpiperidinyl-N-oxyl (TEMPO)-Mediated α-Cyanation and Phosphonylation of Cyclic Amines with Metal-Free Conditions

Junqing Gao, Xinjun Weng, Cong Ma, Xuetao Xu, Ping Fang, Tiansheng Mei

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3223-3234 DOI: 10.6023/cjoc202103049

Abstract( 1378) HTML( 176) PDF(1749KB)( 1640 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Palladium-Catalyzed Synthesis of 1H-Indol-3-yl Acrylates from 2-Alkynyl Arylazides and Acrylic Acids

Ping Li, Zhiqiang Zhou, Fan Yang, Yao Xu, Xiaoxiang Zhang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3235-3241 DOI: 10.6023/cjoc202101047

Abstract( 672) HTML( 6) PDF(542KB)( 491 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Copper-Catalyzed the Synthesis of 3-Trifluoromethylchromone via Trifluoromethyl Radical Addition Tandem Cyclization Reaction of 2-Hydroxyphenyl Enaminones

Keying Du, Zhanming Zhang, Weijian Sheng

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3242-3248 DOI: 10.6023/cjoc202102007

Abstract( 725) HTML( 23) PDF(601KB)( 889 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Phosphine Oxide-Directed Palladium-Catalyzed Heck-Type Functionalization of o-Carboranes

Lingxiang Lian, Jingyi Yin, Caixia Lin, Keyin Ye, Yaofeng Yuan

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3249-3255 DOI: 10.6023/cjoc202103015

Abstract( 609) HTML( 15) PDF(574KB)( 531 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Highly Efficient Synthesis of 1H-Indazole-3-carboxylic Acid Derivatives via Diazotization Reaction

Changming Xu, Jincheng Huang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3256-3263 DOI: 10.6023/cjoc202103008

Abstract( 1155) HTML( 17) PDF(642KB)( 912 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Ligand-Free Pd-Catalyzed Hydrophosphorylation of Internal Alkynes for the Synthesis of E-Vinylphosphonates

Zhenli Xu, Zongxue Zhang, Chenxiang Meng, Xiaoya Zhang, Kai Xu, Lantao Liu, Tao Wang, Haiyun Xu, Guoliang Mao

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3264-3271 DOI: 10.6023/cjoc202103038

Abstract( 562) HTML( 6) PDF(672KB)( 536 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Mechanistic Understanding of Rh(III)-Catalyzed Redox-Neutral C—H Activation/Annulation Reactions of N-Phenoxyacetamides and Methyleneoxetanones

Man Xu, Yuanzhi Xia

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3272-3278 DOI: 10.6023/cjoc202103054

Abstract( 625) HTML( 17) PDF(761KB)( 803 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

NOTES

Alkoxylation of para-Quinone Methides via Bismuth Complex Catalyzed 1,6-Addition Reactions of Alcohols

Hanlin Li, Donglan Liu, Liang Chen, Haiyan Xu, Hongfei Lu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3279-3284 DOI: 10.6023/cjoc202103018

Abstract( 597) HTML( 17) PDF(1055KB)( 428 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Ammonium Persulfate Promotes Trifluoromethylation of Quinoxalin-2(1H)-ones

Rongnan Yi, Dongxian Liu, Jiangnan He, Mingming Zhao, Xinhua Xu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3285-3291 DOI: 10.6023/cjoc202012046

Abstract( 654) HTML( 8) PDF(518KB)( 617 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Total Synthesis and Anti-inflammatory Evaluation of Dorsmerunin A

Minxin Li, Qiuping Zou, Wenrong Du, Jinchun Gao, Yanping Li, Zewei Mao

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3292-3296 DOI: 10.6023/cjoc202102040

Abstract( 484) HTML( 5) PDF(933KB)( 687 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Combinatorial Biosynthesis Mediates the Discovery of Novel Tetracyclines with Isomerized C-4 Hydroxyl

Shijie Li, Qiuyue Nie, Zhenyu Ji, Huiming Hua, Gongli Tang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3297-3302 DOI: 10.6023/cjoc202103033

Abstract( 482) HTML( 10) PDF(575KB)( 718 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Synthesis, Characterization, and Biological Activity of Novel Amide Derivatives Containing Trifluoromethylpyridine Moieties

Feng He, Shengxin Guo, Ali Dai, Renfeng Zhang, Jian Wu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3303-3311 DOI: 10.6023/cjoc202101045

Abstract( 659) HTML( 15) PDF(612KB)( 867 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Design and Synthesis of Pyridine and 1,3,5-Triazine PNP Pincer Ligands and Their Application in Cobalt Catalyzed Semihydrogenation of Terminal Alkynes

Yinyin Wang, Xiaowan Lin, Piao Zhang, Meihua Shen, Huadong Xu, Defeng Xu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3312-3320 DOI: 10.6023/cjoc202102050

Abstract( 679) HTML( 9) PDF(588KB)( 805 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Design and Synthesis of Novel Nature-Inspired Stilbene Analogues as Potential Topoisomerase 1 Inhibitors

Qi Lu, Feixia Ye, Xiaotong Sun, Jianquan Weng, Qian Yu, Dexuan Hu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3321-3329 DOI: 10.6023/cjoc202102031

Abstract( 541) HTML( 11) PDF(1848KB)( 638 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

Deoxygenation of Sulfoxides with Dimethylthiocarbamoyl Chloride in the Absence of Additional Solvent

Xingyue Wang, Changlin Xu, Hongyu Guan, Mi Lin, Peng Huang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3330-3334 DOI: 10.6023/cjoc202102004

Abstract( 539) HTML( 4) PDF(476KB)( 660 )

Fig. & Tab. | References | Supporting Info. | Related Articles | Metrics

HIGHLIGHTS

Asymmetric Transfer Hydrogenation via a Chiral Antimony(V) Cation/Anion Pair

Xiangqing Feng, Haifeng Du

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3335-3336 DOI: 10.6023/cjoc202100057

Abstract( 354) HTML( 16) PDF(442KB)( 498 )

Fig. & Tab. | References | Related Articles | Metrics

Stereodivergent Pd/Cu Catalysis for the Construction of Allenyl Axial Chirality and Central Chirality

Xiaohong Huo, Wanbin Zhang

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3337-3338 DOI: 10.6023/cjoc202100058

Abstract( 1127) HTML( 34) PDF(421KB)( 1228 )

Fig. & Tab. | References | Related Articles | Metrics

Ru(II)-Catalyzed Asymmetric Synthesis of S-Chiral Heterocyclic Sulfoximines

Qiong Wu, Feng Shi

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3339-3341 DOI: 10.6023/cjoc202100059

Abstract( 426) HTML( 22) PDF(540KB)( 610 )

Fig. & Tab. | References | Related Articles | Metrics

Highly Regio- and Enantio-selective Reductive Coupling of Aldehydes and Alkynes via Photoredox Cobalt Dual Catalysis

Binyang Jiang, Shi-Liang Shi

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3342-3343 DOI: 10.6023/cjoc202100060

Abstract( 554) HTML( 27) PDF(439KB)( 916 )

Fig. & Tab. | References | Related Articles | Metrics

Rhodium-Catalyzed Regio- and Enantio-selective Allylic Amination of Racemic 1,2-Disubstituted Allylic Phosphates

Yuqing Zheng, Wenbo Liu

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3344-3345 DOI: 10.6023/cjoc202100061

Abstract( 464) HTML( 19) PDF(460KB)( 623 )

Fig. & Tab. | References | Related Articles | Metrics

Cu-Catalyzed Asymmetric Difluoromethylation of Amino Acids with Difluorocarbene

Jinhong Lin, Jichang Xiao

Chinese Journal of Organic Chemistry 2021, 41 (8), pp 3346-3348 DOI: 10.6023/cjoc202100062

Abstract( 482) HTML( 30) PDF(440KB)( 973 )

Fig. & Tab. | References | Related Articles | Metrics