Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (10): 3983-3994.DOI: 10.6023/cjoc202104020 Previous Articles     Next Articles

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自组装多肽的修饰方法及其应用

任涵a,b, 李茹祥a,b, 陈志坚a,*(), 李莉莉b,*(), 王浩b,*()   

  1. a 天津大学化工学院 天津 300350
    b 国家纳米科学中心 中国科学院纳米生物效应与安全性重点实验室 北京 100190
  • 收稿日期:2021-04-10 修回日期:2021-05-10 发布日期:2021-05-23
  • 通讯作者: 陈志坚, 李莉莉, 王浩
  • 基金资助:
    国家重点研发计划(2018YFE0205400)

Modification Methods and Applications of Self-Assembly Peptides

Han Rena,b, Ruxiang Lia,b, Zhijian Chena(), Lili Lib(), Hao Wangb()   

  1. a School of Chemical Engineering, Tianjin University, Tianjin 300350
    b CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190
  • Received:2021-04-10 Revised:2021-05-10 Published:2021-05-23
  • Contact: Zhijian Chen, Lili Li, Hao Wang
  • Supported by:
    National Key R&D Program of China(2018YFE0205400)

Self-assembly peptide is a kind of peptide material that can form assembly under certain conditions due to the intermolecular forces such as π-π stacking and electrostatic interaction. This class of material exhibits good biocompatibility and controllability, and can form nanostructures such as granules, fibers and gels, which play a specific morphologic function and are widely used in biomedicine and other fields. In order to meet the needs of drug delivery, disease diagnosis and regulation of hydrophilic hydrophobic balance of peptides, it is necessary to perform modification for peptides. Due to the assembly characteristics of peptides and their biological functions, modified peptides have more advantages than the unmodified ones. Thus, functional modification for self-assembly peptides has been investigated intensively in recent years. The modification sites in peptide are usually the carboxyl and amino groups at both ends, as well as the active groups on the amino acid side chain. However, it is difficult for some molecules to react with peptides directly. Accordingly, two modification methods, i.e. direct and indirect modifications, have been developed in research. In this paper, the recent functionalization methods of self-assembly peptides and relevant applications are reviewed.

Key words: peptide modification, self-assembly, synthetic method, biological application