Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (10): 4083-4087.DOI: 10.6023/cjoc202104054 Previous Articles     Next Articles

NOTES

无配体参与的铁催化分子内C(sp3)—H键胺化合成咪唑啉酮

邬林洋, 钟大猷, 刘文博*()   

  1. 武汉大学化学与分子科学学院 索维奇国际分子科学研究中心 有机硅化合物及材料教育部工程研究中心 武汉 430072
  • 收稿日期:2021-04-26 修回日期:2021-05-09 发布日期:2021-05-14
  • 通讯作者: 刘文博
  • 基金资助:
    国家自然科学基金(21971198); 国家自然科学基金(21772148)

Ligand-Free Iron-Catalyzed Intramolecular Amination of C(sp3)—H Bond for the Synthesis of Imidazolinones

Linyang Wu, Dayou Zhong, Wenbo Liu()   

  1. Sauvage Center for Molecular Sciences, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072
  • Received:2021-04-26 Revised:2021-05-09 Published:2021-05-14
  • Contact: Wenbo Liu
  • Supported by:
    National Natural Science Foundation of China(21971198); National Natural Science Foundation of China(21772148)

Transition-metal-nitrenoids intramolecular C—H insertion is one of the most effective methods to synthesize nitrogen-containing heterocycles. Using 2-azido-N,N-dibenzylacetamides as substrates, an iron-catalyzed intramolecular C(sp3)—H bond amination reaction under ligand-free and external oxidant-free conditions has been developed. A series of imidazolinones were synthesized in moderate to good yields.

Key words: iron catalysis, nitrene insertion, imidazolinone, synthesis of N-containing heterocycles