Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3294-3298.DOI: 10.6023/cjoc201903007 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019


谢庭辉ab, 蒋筱莹a, 米治胜a, 李雪a, 徐小河a, 白仁仁a, 帅棋a, 谢媛媛a*()   

  1. a 浙江工业大学药学院 长三角绿色制药协同创新中心 杭州 310014
    b 台州科技职业学院 浙江台州 318020
  • 收稿日期:2019-03-04 发布日期:2019-07-09
  • 通讯作者: 谢媛媛
  • 基金资助:

Iron/O2-Promoted C-H Bond Functionalization for the Exclusive Synthesis of 2-Quinoline Carboxaldehydes under Microwave Irradiation

Xie Tinghuiab, Jiang Xiaoyinga, Mi Zhishenga, Li Xuea, Xu Xiaohea, Bai Renrena, Shuai Qia, Xie Yuanyuana*()   

  1. a Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceutical, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014
    b College of Agriculture and Bioengineering, Taizhou Vocational College of Science and Technology, Taizhou, Zhejiang 318020
  • Received:2019-03-04 Published:2019-07-09
  • Contact: Xie Yuanyuan
  • Supported by:
    the National Natural Science Foundation of China(21576239)

An one-pot iron-catalyzed oxidative formylation of 2-methylquinolines to produce 2-quinoline carboxaldehydes under microwave irradiation has been achieved by employing O2 as the oxygen donor. The reaction was general for the substrates with a wide range of functional groups, providing a yield of 48%~80%. The preliminary mechanistic studies revealed that the reaction underwent a radical pathway. Advantages of this method include the easy operation, short reaction time and good selectivity.

Key words: 2-quinoline carboxaldehydes, iron catalysis, C-H oxidation, microwave irradiation