Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (5): 1509-1519.DOI: 10.6023/cjoc202111009 Previous Articles     Next Articles



杨明, 黄丹凤*(), 王克虎, 韩侗育, 赵鹏飞, 王凤, 王君姣, 苏瀛鹏, 胡雨来*()   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2021-11-04 修回日期:2021-12-30 发布日期:2022-01-20
  • 通讯作者: 黄丹凤, 胡雨来
  • 基金资助:
    国家自然科学基金(22061037); 国家自然科学基金(21861033); 上海恩氟佳科技有限公司资助项目

Silver-Catalyzed Synthesis of CF3-Substituted 2-Imidazolines

Ming Yang, Danfeng Huang(), Kehu Wang, Tongyu Han, Pengfei Zhao, Feng Wang, Junjiao Wang, Yingpeng Su, Yulai Hu()   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2021-11-04 Revised:2021-12-30 Published:2022-01-20
  • Contact: Danfeng Huang, Yulai Hu
  • Supported by:
    National Natural Science Foundation of China(22061037); National Natural Science Foundation of China(21861033); Shanghai Sinofluoro Chemicals Co., Ltd

The silver salt catalyzed [3+2] cycloaddition reaction of trifluoromethylated N-acylhydrazones and ethyl isocyanoacetate was investigated. The reaction proceeds quickly to produce a series of trifluoromethylated 2-imidazoline compounds in high yields with excellent stereoselectivity, which provides a novel and efficient method for the synthesis of trifluoromethylated 2-imidazoline compounds.

Key words: trifluoromethylated N-acylhydrazone, ethyl isocyanoacetate, [3+2] cycloaddition, 2-imidazoline